299440-17-8

Basic information

• Product Name: 1-(4-BROMO-2-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE
• Synonyms: BIO-FARMA BF000862;4-BROMO-2-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE;1-(4-BROMO-2-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE;4-Bromo-2-fluorophenylhydrazine
• CAS NO: 299440-17-8
• Molecular Formula: C₆H₆BrFN₂
• Molecular Weight: 241.49
• Product Categories: Building Blocks;Chemical Synthesis;Hydrazines;New Products for Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 299440-17-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-BROMO-2-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMO-2-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE(299440-17-8)
• EPA Substance Registry System: 1-(4-BROMO-2-FLUOROPHENYL)HYDRAZINE HYDROCHLORIDE(299440-17-8)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 299440-17-8(Hazardous Substances Data)

Usage

General Description

1-(4-Bromo-2-fluorophenyl)hydrazine hydrochloride is a chemical compound that contains a hydrazine functional group, a bromine atom, and a fluorine atom. It is commonly used as a reagent in pharmaceutical and chemical research. The hydrazine functional group can act as a nucleophile, allowing the compound to be used in a variety of chemical reactions, such as in the synthesis of pharmaceuticals, and in the production of agricultural chemicals. The bromine and fluorine atoms contribute to the compound's electronic and steric properties, making it useful in a wide range of applications. The hydrochloride salt form of this compound enhances its stability and solubility in water, making it easier to handle and use in laboratory settings.

Upstream product

• 367-24-8 4-bromo-2-fluoroaniline 

Downstream Products

• 1260422-44-3 1-(4-bromo-2-fluorophenyl)-3-methyl-1H-1,2,4-triazole 
• 1262106-85-3 3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile 
• 1363144-82-4 3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile 
• 1243205-02-8 3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzoic acid 
• 721970-87-2 2-(4-bromo-2-fluoro-phenyl)-5-methyl-1,2-dihydro-pyrazol-3-one 

Relevant articles and documents

HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.

De novo design and synthesis of HIV-1 integrase inhibitors

Existing AIDS therapies are out of reach for most HIV-infected people in developing countries and, where available, they are limited by their toxicity and their cost. New anti-HIV agents are needed urgently to combat emerging viral resistance and reduce the side effects associated with currently available drugs. Toward this end, LeapFrog, a de novo drug design program was used to design novel, potent, and selective inhibitors of HIV-1 integrase. The designed compounds were synthesized and tested for in vitro inhibition of HIV-1 integrase. Out of the 25 compounds that were designed, and synthesized, four molecules (compounds 23, 26, 43, and 59) showed moderate to low inhibition of HIV-1 integrase for 3′-processing and 3′- strand transfer activities. Nonetheless, these compounds possess structural features not seen in known HIV-1 integrase inhibitors and thus can serve as excellent leads for further optimization of anti-HIV-1 integrase activity.