299440-21-4

Basic information

• Product Name: (2-bromo-4-fluorophenyl)hydrazine
• Synonyms: (2-bromo-4-fluorophenyl)hydrazine
• CAS NO: 299440-21-4
• Molecular Formula: C₆H₆BrFN₂
• Molecular Weight: 205.0276432
• Mol File: 299440-21-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 251.9±30.0 °C(Predicted)
• Appearance: /
• Density: 1.760±0.06 g/cm3(Predicted)
• PKA: 4.62±0.27(Predicted)
• CAS DataBase Reference: (2-bromo-4-fluorophenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromo-4-fluorophenyl)hydrazine(299440-21-4)
• EPA Substance Registry System: (2-bromo-4-fluorophenyl)hydrazine(299440-21-4)

Safety Data

• Hazardous Substances Data: 299440-21-4(Hazardous Substances Data)

Upstream product

• 571170-91-7 (2-bromo-4-fluorophenyl)hydrazine hydrochloride 
• 51991-39-0 5-Hydroxy-1H-indole-2-carboxylic acid methyl ester 
• 1003-98-1 2-bromo-4-fluoroaniline 

Downstream Products

• 1202578-62-8 C₁₁H₁₄BrFN₂O 
• 1202578-67-3 C₁₂H₁₁BrFN₃O₄ 
• 1202578-64-0 C₁₂H₁₂BrFN₂O₂ 
• 1202578-70-8 C₁₂H₁₃BrFN₃O₂ 
• 1322705-12-3 C₂₂H₁₆BrFN₂O₄ 
• 1322705-37-2 C₁₅H₁₀Br₂FN₃O₃ 
• 396076-60-1 ethyl 7-bromo-5-fluoro-1H-indole-2-carboxylate 

Relevant articles and documents

PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT 1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, and G, are defined herein.

Design, Synthesis, and 3D-QSAR Analysis of Novel 1,3,4-Oxadlazol-2(3H)-ones as Protoporphyrlnogen Oxidase Inhibitors

Protoporphyrlnogen oxidase (PPO, EC 1.3.3.4) has been Identified as one of the most significant action targets for a large chemically diverse family of herbicides that exhibit some Interesting characteristics, such as low use rate, low toxicity to mammals, and low environmental Impact. As a continuation of research work on the development of new PPO Inhibitors, some benzothlazole analogues of oxadlargyl, an Important PPO-lnhlbltlng commercial herbicide, were designed and synthesized by ring-closing of the substltuents at the C-4 and C-5 positions. The bloassay results Indicated that the series 8, 9, and 10 have good PPO Inhibition activity with kl values ranging from 0.25 to 18.63 μM. Most Interestingly, 9I, ethyl 2-((5-(5-fert-butyl-2-oxo-1,3,4-oxadlazol- 2(3H)-yl)-6fluorobenzothlazol-2-yl)sulfanyl) propanoate, was Identified as the most promising candidate due to Its high PPO Inhibition effect (kl 1.42 ,μM) and broad spectrum postemergence herbicidal activity at the concentration of 37.5 g of al/ha.

Protein kinase and phosphatase inhibitors and methods for designing them

The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity.