29958-02-9Relevant articles and documents
The Knoevenagel condensation using quinine as an organocatalyst under solvent-free conditions
Jain, Kavita,Chaudhuri, Saikat,Pal, Kuntal,Das, Kalpataru
, p. 1299 - 1304 (2019)
The Knoevenagel condensation between active methylene compounds and aromatic carobonyl compounds has been developed using quinine as an organocatalyst to afford various electrophilic alkenes in excellent yields (up to 90%). In the presence of a catalytic amount of quinine (15 mol%), the reaction proceeded at room temperature (RT) under solvent-free conditions. In this green approach, the organocatalyst was recovered and recycled for up to four cycles without appreciable loss of activity.
Synthetic method of trimethoprim
-
, (2016/10/08)
The invention discloses a synthetic method of trimethoprim. Trimethoprim is synthesized from 3,4,5-trimethoxybenzaldehyde and ethyl cyanoacetate. The method has the advantages of high conversion rate, short time, and industrial production facilitation.
A systematic study on Knoevenagel reaction and Nazarov cyclization of less reactive carbonyl compounds using rare earth triflates and its applications
Ilangovan,Muralidharan,Maruthamuthu
experimental part, p. 1000 - 1006 (2012/02/05)
A systematic study of Knoevenagel reaction and Nazarov cyclization was made on variety of less reactive carbonyl compounds such as β-ketoesters, 1,3-diketones and cyclic active methylene compounds using Yb(OTf)3 as the catalyst. Recycling study confirms reusability of the catalyst without much loss of activity.
One-pot approach for C-C bond formation through ruthenium-amido complex catalyzed tandem aldol reaction/hydrogenation
Sun, Haifeng,Ye, Deju,Jiang, Hualiang,Chen, Kaixian,Liu, Hong
supporting information; experimental part, p. 2577 - 2582 (2010/09/05)
A one-pot novel and efficient approach was developed for the -alkylation of various nitriles with carbonyl compounds using ruthenium-amido complex catalyst 1. The C-C bond was formed through aldol reaction followed by hydrogenation with triethylamine-formic acid (TEAF) and 1. Moderate to high yields were obtained, and a variety of functional groups were tolerated, including nitro and chloro groups, and a furan ring. Georg Thieme Verlag Stuttgart New York.
Unprecedented reaction between ethyl α-cyanocinnamate and o-phenylenediamine: Development of an efficient method for the transfer hydrogenation of electronically depleted olefins
Kumar, Satish,Kapoor, Kamal K.
, p. 2809 - 2814 (2008/02/13)
A reaction between ethyl α-cyanocinnamate and o-phenylenediamine under thermal conditions yielded 2-cyano-3-phenyl-propionic acid ethyl ester, 2-phenyl benzimidazole, and ethyl cyanoacetate. The mechanistic revelations led to the development of a simple and efficient transfer-hydrogenation process from the in situ generated benzimidazolines to activated olefins under solventless and catalyst-free conditions. Georg Thieme Verlag Stuttgart.
An Efficient Knoevenagel Condensation Catalyzed by LaCl3.7H 2O in Heterogeneous Medium
Narsaiah, A. Venkat,Nagaiah
, p. 3825 - 3832 (2007/10/03)
Knoevenagel condensation was carried out in absence of solvent with a mild Lewis acid Lanthanum(III) chloride, to prepare substituted alkenes. A systematic study of the reaction to establish the generality of the method has been undertaken with various aldehydes and active methylene compounds.
An efficient benzyltriethylammonium chloride catalysed preparation of electrophilic alkenes: a practical synthesis of trimethoprim
Bose, D. Subhas,Narsaiah, A. Venkat
, p. 36 - 38 (2007/10/03)
The Knoevenagel condensation of carbonyl compounds with active methylene compounds was readily carried out with benzyltriethylammonium chloride as a catalytic agent, under solvent-free conditions to produce olefinic products in high yeilds: the scope of this protocol is utilised for the synthesis of the antibacterial agent trimethoprim.
