299898-31-0Relevant academic research and scientific papers
Automated synthesis: Utilization of MEDLEY in synthetic processes
Orita, Akihiro,Yasui, Yutaka,Otera, Junzo
, p. 337 - 341 (2000)
A variety of reactions which are commonly used in synthetic chemistry are feasible with the automated synthesizer (MEDLEY). Air-sensitive organolithium and Grignard reagents as well as transition metal catalysts like Ni(0) and Pd(0) species are employable. The precise control of both the reaction temperature and the amount of added reagents enables to examine the dependence of chemical yields on the reaction temperature. Since the order of reagent addition is programmed and the reaction temperature is quickly tunable, sequential reactions can be conducted smoothly. An advanced control system was incorporated which allows a task to start immediately after the preceding one has finished. Owing to this function, the time for completing the multistep process can be minimized.
