299918-29-9

Upstream product

• 299918-23-3 [3-Iodo-1-methyl-5-(2,2,2-trichloro-acetyl)-1H-pyrrol-2-yl]-acetonitrile 
• 299918-22-2 [3-Bromo-1-methyl-5-(2,2,2-trichloro-acetyl)-1H-pyrrol-2-yl]-acetonitrile 
• 299918-25-5 5-cyanomethyl-4-iodo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 299918-24-4 4-bromo-5-cyanomethyl-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 299918-21-1 [1-Methyl-5-(2,2,2-trichloro-acetyl)-1H-pyrrol-2-yl]-acetonitrile 
• 24437-41-0 1-methyl-2-pyrroleacetonitrile 
• 115377-94-1 2-(tert-butoxycarbonylamino)phenylboronic acid 
• 299918-27-7 5-(1-cyano-1-ethyl-propyl)-4-iodo-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 299918-26-6 4-bromo-5-(1-cyano-1-ethyl-propyl)-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 

Downstream Products

• 299918-30-2 2-[3-(2-amino-phenyl)-1-methyl-1H-pyrrol-2-yl]-2-ethyl-butyramide 

Relevant academic research and scientific papers

Synthesis of a rhazinilam analogue acting as an inhibitor of tubulin assembly

The synthesis of a di-nor-secorhazinilam analogue is described. This phenylpyrrole compound has been prepared by a Susuki cross-coupling reaction between 1,2,5 trisubstituted pyrrole halides and 2-N-(tert- butoxycarbonyl)aminophenyl boronic acid. In contrast to rhazinilam, this new phenylpyrrole inhibits the assembly of tubulin into microtubules. (C) 2000 Elsevier Science Ltd.