299926-03-7

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 203064-64-6 tert-butyl (2S,3R)-3-(((benzyloxy)carbonyl)amino)-2-hydroxybutanoate 
• 621-84-1 O-benzyl carbamate 
• 79218-15-8 tert-butyl (E)-crotonate 
• 30830-47-8 benzyl N-chlorocarbamate 

Downstream Products

• 299926-05-9 (2S,3R)-tert-Butyl 2-tert-butyldimethylsilyloxy-3-(N-benzyloxycarbonyl-N-methyl)aminobutanoate 
• 299926-09-3 (1S,2R)-2-(N-Benzyloxycarbonyl-N-methyl)amino-1-(tert-butoxycarbonyl)propyl-1-methanesulfonate 
• 299926-11-7 (2R,3R)-tert-Butyl 2-azido-3-(N-benzyloxycarbonyl-N-methyl)aminobutanoate 
• 299926-07-1 (2S,3R)-tert-Butyl 2-hydroxy-3-(N-benzyloxycarbonyl-N-methyl)aminobutanoate 
• 914090-57-6 5-benzyloxycarbonylamino-4-(tert-butyldimethylsilanyloxy)-hex-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

An asymmetric aminohydroxylation route to cis-2,6-disubstituted piperidine-3-ol: application to the synthesis of (-)-deoxocassine

A highly efficient, flexible, and convergent route to cis-2,3,6-trisubstituted piperidines has been developed employing the Sharpless asymmetric aminohydroxylation and stereoselective reductive amination by catalytic hydrogenation as the key steps. Its usage is illustrated by the short synthesis of the piperidine-3-ol alkaloid, (-)-deoxocassine.

Synthesis of (S,S)- and (R,R)- 2-amino-3-methylaminobutanoic acid (AMBA)

The synthesis and characterization of (S, S)- and (R, R)-2-amino-3-methylaminobutanoic acid starting from tert-butyl crotonate is described.