299937-04-5Relevant articles and documents
Molecular hybridization based design and synthesis of new benzo[5,6]chromeno[2,3-b]-quinolin-13(14H)-one analogs as cholinesterase inhibitors
Macha, Baswaraju,Kulkarni, Ravindra,Bagul, Chandrakant,Garige, Anil Kumar,Akkinepally, Raghuramrao,Garlapati, Achaiah
, p. 685 - 701 (2021)
A Series of new tacrine analogs were designed, synthesized, characterized by respective spectral data and evaluated for cholinesterase inhibitory activity to be useful in Alzheimer’s disease. Most of the synthesized compounds showed good in vitro inhibitory activities toward acetyl cholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. Among the compounds, 6i, 6o and 6r with increased saturated carboxylic ring size attached to the pyridine moiety and having 3,4-dihydroxy, 3,4,5-trimethoxy substituents on the aromatic ring attached at the stereogenic center have shown equal potency to that of tacrine with IC50values 0.65 ± 0.06, 1.32 ± 0.02 and 0.85 ± 0.05, 1.65 ± 0.12 and 0.92 ± 0.03, 1.91 ± 0.12 μM against AChE and BuChE, respectively. Standard drug tacrine exhibited IC50 values of 0.47 ± 0.02 and 0.65 ± 0.08, while Donepezil showed IC50 0.71 ± 0.06 and 0.31 ± 0.04 μM against AChE and BuChE, respectively. Docking studies of all the molecules disclosed close hydrogen bond interactions with the binding site.
Nano polypropylenimine dendrimer (DAB-PPI-G1): As a novel nano basic-polymer catalyst for one-pot synthesis of 2-amino-2-chromene derivatives
Maleki, Behrooz,Sheikh, Safoora
, p. 42997 - 43005 (2015/05/27)
The nano polypropylenimine dendrimer (DAB-PPI-G1) Lewis base catalyst was found to be a highly efficient and recoverable catalyst for the rapid and convenient synthesis of 2-amino-2-chromene derivatives through the three-component condensation of aromatic aldehydes, malononitrile or ethyl cyanoacetate and phenols under solvent-free conditions in excellent yields and short reaction times.
Potassium phthalimide-catalysed one-pot multi-component reaction for efficient synthesis of amino-benzochromenes in aqueous media
Kiyani, Hamzeh,Ghorbani, Fatemeh
, p. 1104 - 1112 (2014/05/20)
2-Amino-4-aryl-4H-benzo[h]chromenes and 3-amino-1-aryl-1H-benzo[f]chromenes were prepared by treating cyano-methylene compounds (malononitrile or ethyl cyanoacetate), substituted aromatic aldehydes, and naphtholic compounds in the presence of potassium phthalimide as a green, mild, efficient, and commercially available organocatalyst in aqueous media. The procedure was readily conducted and affords remarkable advantages such as safety, short reaction times, environmentally benign milder reaction conditions, no organic solvent required, and high yields.
