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Relevant academic research and scientific papers

Solvent free, environment benign synthesis of 1,4-dihydropyridines and polyhydroquinolines by using heterogeneous Zn/MCM-41 catalyst

Heterogeneous catalysis has been utilized in number of efficient reactions with higher selectivity of the product, more stable, reusable and easy for separation as compared to homogeneous catalysts. Generally, heterogeneous catalysts are prepared by using mesoporous materials, microporous materials, metal oxides and metal organic framework. The mesoporous materials have small particle size and high surface area as compared to the microporous materials. The adsorbent mesoporous materials have highly efficient for the therapeutic applications in chemistry hence it has best as compared to other heterogeneous materials. Herein, we have reported synthesis of 1,4-dihydropyridines and polyhydroquinolines at solvent free and environmental benign condition in the presence of Zn/MCM-41 catalyst. The present protocol gives excellent yield (89–96%) of the product within short reaction time by easy work up procedure and no need of further purification of product. The catalyst was characterized by XRD diffractometer, SEM, EDAX, TGA-DTA, BET surface area analysis and FT-IR Spectroscopy. The synthesized organic compounds were characterized by FT-IR, 1H NMR, 13C NMR, LC–MS spectrometry. Graphical abstract: [Figure not available: see fulltext.]

Aluminized polyborate-catalysed green and efficient synthesis of polyhydroquinolines under solvent-free conditions

Abstract: The present work reports a catalytic application of aluminized polyborate for the solvent-free one pot four-component green, efficient and cost-effective synthesis of polydroquinoline derivatives. The aluminized polyborate was synthesized from r

Sulfated polyborate as an eco-compatible solid acid catalyst for efficient and facile solvent-free synthesis of polyhydroquinolines

Abstract: An environmentally viable, green and efficient protocol for the synthesis of polyhydroquinolines using sulfated polyborate catalyst have been developed by Hantzsch four-component condensation between aromatic aldehydes, dimedone, ammonium acetate and ethylacetoacetate or ethylcyanoacetate at 100?°C under solvent-free condition. The sulfated polyborate catalyst is characterized by FT-IR, XRD, SEM and EDAX techniques. The noticeable features of this methodology are mild Br?nsted acidic nature of the catalyst, good to excellent product yields (85–94%), short reaction time (18–30 min), solvent-free condition, operational simplicity and applicability to a wide range of substrates (29 examples). Graphic Abstract: This work deals with sulfated polyborate catalysed green and efficient solvent-free synthesis of polyhydroquinolines.[Figure not available: see fulltext.]

Fe3-xTixO4-supported sulfamic acid nanoparticles: New magnetic nanocatalyst for the synthesis of hexahydroquinolines

A novel acidic nanocatalytic system, sulfamic acid-functionalized Fe3-xTixO4 magnetic nanoparticles (MNPs), were synthesized through one-pot reaction of Fe3-xTixO4 MNPs with 3-chloropropyltrimethoxysilane and imidazolidine-2,4-dione followed by functionalization with chlorosulfonic acid. The structure of this newly synthesized nanocatalyst was established by several analysis methods including, Fourier-transform infrared (FTIR) and energy-dispersive X-ray (EDX) spectroscopies, transmission (TEM) and scanning (SEM) electron microscopies, thermal gravimetric (TG), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). The potential catalytic ability of this nanocatalyst was evaluated in one-pot four-component condensation reaction between aromatic aldehydes, dimedone, alkyl acetoacetates and ammonium acetate in order to synthesis of hexahydroquinoline derivatives. The reactions proceeded smoothly under solvent-free condition offering excellent yields of corresponding hexahydroquinolines successfully. In addition, the fabricated nanocatalyst exhibited excellent reusability up to four subsequent runs.

Sulfamic acid immobilized on amino-functionalized magnetic nanoparticles: A new and active magnetically recoverable catalyst for the synthesis of N-heterocyclic compounds

Sulfamic acid immobilized on amino-functionalized magnetic nanoparticles (MNPs/DETA-SA) was successfully fabricated and characterized using various techniques. Diameters of approximately 15?nm for the MNPs/DETA-SA were observed from scanning electron microscopy images. The as-fabricated nanocomposite was applied as an efficient and magnetically reusable catalyst for the synthesis of 2,3-dihydroquinazoline-4(1H)-one and polyhydroquinoline derivatives. All products were obtained in good to excellent yields. Recovery tests confirm that the catalyst can be readily recovered using an external magnet and reused many times without significant loss of its catalytic activity.

Choline chloride catalyzed eco-friend and effective one-pot synthesis of 9-arylacridine-1,8-dione and hexahydroquinoline via Hantzsch type reaction

Choline chloride was utilized to efficiently catalyzed Hantzsch type reaction for the synthesis of 9-arylacridine-1,8-dione and hexahydroquinoline derivatives. The optimized catalytic system benefits from facile operation and separation procedures, in goo

Green synthesis of Ni-Cu-Zn ferrite nanoparticles using tragacanth gum and their use as an efficient catalyst for the synthesis of polyhydroquinoline derivatives

Ni0.35Cu0.25Zn0.4Fe2O4 MNPs were synthesized using tragacanth gum as biotemplate and Metals nitrate as the metal source by the sol–gel method. The sample was characterized by powder X-ray diffraction

Synthesis and characterization of DETA/Cu(NO3)2 supported on magnetic nanoparticles: a highly active and recyclable catalyst for the solvent-free synthesis of polyhydroquinolines

Abstract: A new magnetically separable catalyst consisting of Cu(II) complex immobilized on Fe3O4 nanoparticles functionalized with diethylenetriamine (Fe3O4–DETA–Cu(II)) was successfully synthesized and charact

Magnetite polycitric acid (Fe3O4@PCA) nanoparticles: A novel, efficient and reusable solid acid catalyst for the preparation of polyhydroquino-lines

Background: Polyhydroquinoline derivatives are known as one of the most significant class of biologically active heterocycles. Herein, in this paper, magnetite polycitric acid (Fe3O4@PCA) nanoparticles as novel, efficient and reusabl