299947-39-0

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 126-81-8 dimedone 
• 14205-39-1 methyl 3-aminocrotonate 
• 141-97-9 ethyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 1408382-75-1 C₂₅H₂₆N₂O₃ 
• 1408382-74-0 C₂₇H₂₉NO₄ 
• 1408382-70-6 C₂₆H₂₇NO₃ 
• 1349689-15-1 C₂₆H₂₆ClNO₃ 

Relevant academic research and scientific papers

Zn/MCM-41-catalyzed unsymmetrical Hantzsch reaction and the evaluation of optical properties and anti-cancer activities of the polyhydroquinoline products

Abstract: The three-component Hantzsch condensation of various aryl aldehydes, dimedone, and methyl 3-aminocrotonate was investigated in the presence of MCM-41-supported ZnNO3. The polyhydroquinoline products which were obtained under mild cond

Sulfuric acid heterogenized on magnetic Fe3O4 nanoparticles: A new and efficient magnetically reusable catalyst for condensation reactions

Immobilized sulfuric acid on magnetic Fe3O4 nanoparticles (Fe3O4 MNPs-OSO3H) as a new solid acid nanocomposite was successfully synthesized and its catalytic activity in a series of condensation reactions was studied. High catalytic activity, simple separation from reaction mixture by an external magnet and good reusability are several eco-friendly advantages of this catalytic system. It is noteworthy that this catalytic system is applicable to a wide range of spectrum of aromatic aldehydes, and the desired products were obtained in good to excellent yields under mild conditions. The use of ecofriendly solvents makes also this synthetic protocol ideal and fascinating from the environmental point of view.

Sucrose chelated auto combustion synthesis of BiFeO3 nanoparticles: Magnetically recoverable catalyst for the one-pot synthesis of polyhydroquinoline

Sucrose chelated Bismuth ferrite (BiFeO3) nanoparticles as a novel heterogeneous catalyst was synthesized by an auto combustion route. Different calcination temperatures (150?°C, 450?°C, 550?°C, 650?°C, 750?°C and 850?°C) have been employed to obtain single phased BiFeO3 nanoparticles. The perovskite structure formation and disappearance of organic phase (sucrose) was obtained by Fourier transform infrared spectroscopy (FT-IR). Phase determination and structural characterization was carried out by powder X-ray diffraction (XRD). The magnetic properties were analyzed by vibrating sample magnetometer (VSM) whereas surface area/pore volume was obtained by Brunauer–Emmett–Teller (BET). Transmission electron microscope (TEM) analyzed the particles size and morphology. Thermal stability was investigated by thermogravimetric analysis (TGA) and determination of constituent elements was carried out by X-ray Photo-Electron Spectroscopy (XPS). Raman spectroscopy confirmed the perovskite structure of the synthesized materials. The BiFeO3 nanoparticles so obtained were employed as heterogeneous catalyst for the synthesis of polyhydroquinoline derivatives. All the polyhydroquinoline derivatives were characterized by Fourier transform infrared spectroscopy (FT-IR) and Nuclear magnetic resonance spectroscopy (1H NMR). For the very first time ever we have used BiFeO3 as a recyclable magnetic nanocatalyst in the one-pot four component cyclization reaction of benzaldehyde, ethylacetoacetate/methylacetoacetate, dimedone/cyclohexane-1,3-dione, and ammonium acetate for the synthesis of polyhydroquinoline derivatives without solvent under refluxing conditions to provide excellent yields of products. BiFeO3 nanocatalyst (without any functionalization/surface coatings) shows easy magnetic separation, recyclability, reusability along with excellent yield of polyhydroquinoline derivatives in an economic and benign way.

Chitosan: a sustainable, reusable and biodegradable organocatalyst for green synthesis of 1,4-dihydropyridine derivatives under solvent-free condition

Abstract: Chitosan, a biodegradable green catalyst, was found to be an impressive system for one-pot four-component reaction of different aldehydes, dimedone, β‐ketoesters or acetoacetanilide, and ammonium acetate leading to 1,4-dihydropyridine derivatives via Hantzsch-type condensation under solvent-free condition. This methodology produces diverse superiorities such as operational simplicity, short reaction time, satisfied yield and recyclable catalyst. In this work, we attempted to develop several modifications for the classical Hantzsch conversion to report a novel eco-friendly method that is free from previously reported disadvantages. Graphical Abstract: [Figure not available: see fulltext.]

Design, characterization and application of silica-bonded imidazolium-sulfonic acid chloride as a novel, active and efficient nanostructured catalyst in the synthesis of hexahydroquinolines

Abstract novel nanostructured catalyst namely silica-bonded imidazolium-sulfonic acid chloride (SBISAC) was prepared, and fully characterized by several techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), differential thermal gravimetric (DTG), scanning electron microscope (SEM), transmission electron microscopy (TEM) and energy dispersive X-ray analysis (EDX). The nano-compound was applied as an efficient and heterogeneous catalyst in the synthesis of hexahydroquinolines via the one-pot multi-component condensation of arylaldehydes with dimedone (5,5-dimethylcyclohexane-1,3-dione), β-ketoesters and ammonium acetate under mild and solvent-free conditions.

Nano-ferrous ferric oxide (nano-Fe3O4): Magnetite catalytic system for the one-pot four-component tandem imine/enamine formation-Knoevenagel-Michael-cyclocondensation reaction of dimedone, aldehydes, β-ketoesters and ammonium acetate under green media

In this work, magnetite nano-Fe3O4 was applied as a green, efficient, heterogeneous and reusable catalytic system for the atomic economic preparation of hexahydroquinolines via the one-pot multi-component reaction of aryl aldehydes, dimedone (5,5-dimethylcyclohexane-1,3-dione), β-ketoesters and ammonium acetate at 50 °C under mild and solvent-free conditions. The catalyst was synthesized and characterized by several techniques including Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), vibrating sample magnetometry (VSM) and transmission electron microscopy (TEM). Also, optimization of the reaction conditions was investigated using the response surface method {Central Composite Design (CCD)}. the Partner Organisations 2014.

Synthesis of hexahydroquinolines using the new ionic liquid sulfonic acid functionalized pyridinium chloride as a catalyst

Sulfonic acid functionalized pyridinium chloride [pyridine-SO 3H]Cl has been synthesized as a novel Broensted acidic ionic liquid and characterized on the basis of its FT-IR, 1H and 13C NMR, MS, thermogravimetry, and derivative thermogravimetry data. The material has also been used as a highly efficient, homogeneous, and reusable catalyst for the preparation of hexahydroquinolines according to the one-pot multi-component condensation of arylaldehydes, dimedone (5,5- dimethylcyclohexane-1,3-dione), β-ketoesters, and ammonium acetate under solvent-free conditions.

Synthesis, characterization and application of ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate as an efficient catalyst for the preparation of hexahydroquinolines

In this work, novel Br?nsted acidic ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate {[Dsim]HSO4} is synthesized, and characterized by studying its FT-IR, 1H NMR, 13C NMR, mass, TG, DTG and XRD spectra. This ionic liquid, with three acidic functional groups, is utilized as a highly efficient, homogeneous and reusable catalyst for the preparation of hexahydroquinolines via one-pot multi-component condensation of arylaldehydes, dimedone (5,5-dimethylcyclohexane-1,3-dione), β-ketoesters and ammonium acetate under solvent-free conditions. The catalyst can form dual hydrogen-bond using its SO3H groups which this subject can direct to its assembly and efficiency.