299957-33-8

Upstream product

• 299957-31-6 (Z)-5-benzylidene-2,4-dioxo-1-methyl-pyrrolidine-3,3'-spiro-2'-phenyloxirane 
• 299957-27-0 2-Phenyl-6-[1-phenyl-meth-(Z)-ylidene]-1-oxa-5-aza-spiro[2.4]heptane-4,7-dione 
• 108045-40-5 3,5-Bis-benzyliden-pyrrolidin-2,4-dion 
• 186581-53-3 diazomethane 
• 299957-21-4 3-Hydroxy-1-methyl-4-phenyl-6-[1-phenyl-meth-(Z)-ylidene]-1,6-dihydro-pyridine-2,5-dione 

Relevant academic research and scientific papers

Grevellin Analogs with Affinity to the N-Methyl-D-aspartate (Glycine Site) Receptor, a Novel Lead Structure

A series of piperidine-2,3,5-triones (azagrevellins) has been prepared. A new synthesis has been introduced using the rearrangement of spiroepoxides in the presence of triethyloxonium tetrafluoroborate. The binding affinity toward the N-methyl-D-aspartate (glycine site) receptor has been measured to provide a basis for more detailed structure-activity studies. Azagrevellin 18d showed the highest binding potency.