299966-25-9

Upstream product

• 1993-03-9 o-fluorophenylboronic acid 
• 145013-65-6 4-Chloro-8-methoxy-5-nitroquinoline 
• 299966-23-7 8-methoxy-5-nitroquinoline-4-one 
• 299966-22-6 5-[(2'-methoxy-5'-nitrophenylamino)methylene]-2,2-dimethyl-4,6-dioxo-1,3-dioxane 
• 99-59-2 3-amino-4-methoxynitrobenzene 

Downstream Products

• 299966-26-0 8-methoxy-5-amino-4-(2'-fluorophenyl)quinoline 
• 299966-28-2 ethyl 2-[N-[8-methoxy-4-(2'-fluorophenyl)quinolin-5-yl]hydrazono]propionate 

Relevant academic research and scientific papers

Divergent Syntheses of Pyridoacridine Alkaloids via Palladium-Catalyzed Reductive Cyclization with Nitro-Biarenes

A divergent and novel protocol for the preparation of both pyrido[2,3,4-kl]acridine and pyrido[4,3,2-kl]acridine alkaloids was developed. This method featured the remote palladium-catalyzed reductive cyclization with Mo(CO)6 as reductant. A wide range of substrates including three types of nitro arenes were tolerated and afforded corresponding products in good to excellent yields. This method has been successfully applied to the total synthesis of norsegoline, styelsamine C and the skeleton of necatorone.

The first synthesis of the pentacyclic pyridoacridine marine alkaloids: Arnoamines A and B

The synthesis of the marine pyridoacridine alkaloids arnoamines A and B has been accomplished in six and seven steps from 4-chloro-8-methoxy-5-nitroquinoline in 13% and 4% overall yield, respectively.