300-34-5 Usage
Description
3-Amino-L-tyrosine is a non-proteinogenic amino acid characterized by the presence of an additional amino group in the para position on the benzene ring of tyrosine. It is recognized for its role as a precursor in the biosynthesis of various natural products and pharmaceuticals, and has garnered interest in medicinal chemistry due to its antioxidant properties and its capacity to boost neurotransmitter production, particularly dopamine.
Uses
Used in Pharmaceutical Industry:
3-Amino-L-tyrosine is used as a precursor in the synthesis of pharmaceuticals for its ability to contribute to the production of essential neurotransmitters and its potential role in the development of new drugs targeting dopamine receptors.
Used in Neurodegenerative Disorder Treatment:
3-Amino-L-tyrosine is utilized as a therapeutic agent for neurodegenerative disorders such as Parkinson's disease, due to its potential to enhance dopamine levels and mitigate the effects of these conditions.
Used in Medicinal Chemistry Research:
3-Amino-L-tyrosine serves as a subject of interest in medicinal chemistry research, where it is explored for its antioxidant properties and its capacity to influence neurotransmitter synthesis, offering avenues for the treatment of various neurological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 300-34-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 300-34:
(5*3)+(4*0)+(3*0)+(2*3)+(1*4)=25
25 % 10 = 5
So 300-34-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2O3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,10-11H2,(H,13,14)
300-34-5Relevant articles and documents
Conversion of a Dehalogenase into a Nitroreductase by Swapping its Flavin Cofactor with a 5-Deazaflavin Analogue
Su, Qi,Boucher, Petrina A.,Rokita, Steven E.
supporting information, p. 10862 - 10866 (2017/08/30)
Natural and engineered nitroreductases have rarely supported full reduction of nitroaromatics to their amine products, and more typically, transformations are limited to formation of the hydroxylamine intermediates. Efficient use of these enzymes also requires a regenerating system for NAD(P)H to avoid the costs associated with this natural reductant. Iodotyrosine deiodinase is a member of the same structural superfamily as many nitroreductases but does not directly consume reducing equivalents from NAD(P)H, nor demonstrate nitroreductase activity. However, exchange of its flavin cofactor with a 5-deazaflavin analogue dramatically suppresses its native deiodinase activity and leads to significant nitroreductase activity that supports full reduction to an amine product in the presence of the convenient and inexpensive NaBH4.
