30007-57-9Relevant academic research and scientific papers
Convergent Route to β-Amino Acids and to β-Heteroarylethylamines: An Unexpected Vinylation Reaction
Chen, Xuan,Zard, Samir Z.
, (2020/05/05)
Various protected β2-amino acids can be prepared by radical addition of β-phthalimido-α-xanthyl propionic acid, both as the free acid or as the ethyl ester. Successive radical additions provide access to more complex structures. In the case of the free acid, addition to certain heteroaromatics leads directly to β-heteroarylethylamines through spontaneous decarboxylation of the intermediate adduct. Forcing the decarboxylation in some cases generated a vinyl group by decarboxylative elimination of the phthalimido group.
FORMATION OF DERIVATIVES OF THIAZOLINE BY THE REACTION OF THIOUREA WITH 2-BROMO-3-AMINOPROPIONIC ACID
Golubev, A. A.,Semenenko, M. N.,Mandrugin, A. A.,Fedoseev, V. M.
, p. 1367 - 1369 (2007/10/02)
Depending on the conditions employed, thiourea reacts with the hydrobromide of 2-bromo-3-aminopropionic acid to give a dihydrobromide of an internal salt S-(2-amino-1-carboxyethyl)isothiourea.This compound can also lose ammonia to give a thiazoline derivative.
