30011-36-0

Usage

Biochem/physiol Actions

Dopamine β-hydroxylase inhibitor.

Upstream product

• 124316-00-3 1-<<(Triphenylphosphoranylidene)amino>methyl>benzotriazole 
• 4440-01-1 lithium phenylacetylide 
• 4656-94-4 2-(3-phenylprop-2-yn-1-yl)isoindoline-1,3-dione 
• 512785-77-2 (3-phenyl-prop-2-ynyl)-carbamic acid tert-butyl ester 
• 591-50-4 iodobenzene 
• 92136-39-5 N-tert-Butoxycarbonyl-1-amino-3-propyne 

Downstream Products

• 71616-35-8 2N-(3-phenylprop-2-yn-1-yl) acetamide 
• 27975-60-6 ethyl 3-phenyl-2-propynyl ether 
• 157022-42-9 ethyl 1-phenyl-2-propynyl ether 
• 157022-40-7 (3-diazoprop-1-yn-1-yl)benzene 
• 157022-37-2 3-(N-nitrosoacetamido)-1-phenylpropyne 
• 1610970-47-2 C₁₀H₁₁BN₂ 
• 1610970-58-5 C₉H₁₂BN 
• 1610970-60-9 C₁₆H₁₅BN₂ 
• 1610970-32-5 C₁₀H₁₁BN₂ 
• 1333470-72-6 (5Z)-5-benzylidene-2-phenyl-4,5-dihydro-1,3-oxazole 
• 1324498-95-4 4-chloro-N-(3-phenylprop-2-yn-1-yl)benzamide 
• 305837-95-0 4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Design, Synthesis and Biological Evaluation of Bengamide Analogues as ClpP Activators

To combat multidrug-resistant Gram-positive bacteria, new antimicrobials particularly those with novel mechanism of action are badly needed. Different with conventional antibiotics which are typical inhibitors, small-molecule activators of bacterial ClpP represent a new class of antibiotics. No ClpP activator has been developed for clinical trial. Herein, we conducted a screening on our library of bengamide-like ring-opened analogues and found that L472-2 possesses a low minimum inhibitory concentration (MIC) against S.aureus and shows no activity for ClpP activation in vitro, but it displayed reduced antibacterial activity against S. aureus with clpP deletion. In order to obtain bengamide analogues that activate ClpP in vitro as well as possess antibacterial activity, we perform further structural modifications starting from L472-2. Compound 37 remains the antimicrobial activity and activation of ClpP protein in vitro, which could be viewed as a new chemical scaffold for ClpP activators and worthy of further investigation.

Dual use of propargylamine building blocks in the construction of polyheterocyclic scaffolds

The cyclization reactions of 2-(N-propargyl)imidazole-2-yl)indoles (synthesized via the hydroamination reaction between N-propargyl indole-2-carboxamides and propargylamine) have been investigated under Lewis acid- and base-promoted conditions. The polyhe

Silver-Catalyzed Cyclization of Propargylic Amides to Oxazolines

A ligand-accelerated effect is observed in the cyclization of propargylic amides catalyzed by bis(pyridyl)silver(I) complexes, with an unexpected reversal of electronic demand to the analogous NH addition reaction. The catalyst was found to be effective for internal alkyne substrates, offering exclusive selectivity for the 5-exo-dig product. Differences in selectivity profile between gold- and silver-catalyzed processes are highlighted and discussed.

Synthesis of cyclic amine boranes through triazole-Gold(I)-catalyzed alkyne hydroboration

The first catalytic alkyne hydroboration of propargyl amine boranecarbonitriles is accomplished with triazole-AuI complexes. While the typical [L-Au]+ species decomposes within minutes upon addition of amine boranecarbonitriles, the

N-Triphenylphosphorylidene-1-(benzotriazol-1-yl)methylamine, a Novel Synthon Equivalent to +CH2NH2: The Preparation of Primary Amines

Primary amines are readily prepared by reaction of the title compound with organolithiums or Grignard reagents.