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3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide is a chemical compound with the molecular formula C18H21N3O3S2. It is an amide derivative featuring a thiazole ring and a cyclopentyl group. 3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE has potential pharmaceutical applications due to its unique structural features, including a sulfonyl group that may contribute to its chemical reactivity and biological properties. Further research is necessary to explore its full potential uses and effects.

300352-96-9

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300352-96-9 Usage

Uses

Used in Pharmaceutical Industry:
3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide is used as a potential pharmaceutical agent for its possible biological activity. The presence of the thiazole ring and sulfonyl group may provide unique interactions with biological targets, making it a candidate for drug development.
Used in Research and Development:
In the field of chemical research, 3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide serves as a subject for further investigation into its chemical properties, reactivity, and potential applications in medicinal chemistry. Understanding its behavior can lead to the discovery of new therapeutic agents or chemical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 300352-96-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,3,5 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 300352-96:
(8*3)+(7*0)+(6*0)+(5*3)+(4*5)+(3*2)+(2*9)+(1*6)=89
89 % 10 = 9
So 300352-96-9 is a valid CAS Registry Number.

300352-96-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)pr opanamide

1.2 Other means of identification

Product number -
Other names 3-Cyclopentyl-1-isopropyl-benzol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:300352-96-9 SDS

300352-96-9Downstream Products

300352-96-9Relevant academic research and scientific papers

Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2 R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N- thiazol-2-yl-propionamide (RO0281675)

Haynes, Nancy-Ellen,Corbett, Wendy L.,Bizzarro, Fred T.,Guertin, Kevin R.,Hilliard, Darryl W.,Holland, George W.,Kester, Robert F.,Mahaney, Paige E.,Qi, Lida,Spence, Cheryl L.,Tengi, John,Dvorozniak, Mark T.,Railkar, Aruna,Matschinsky, Franz M.,Grippo, Joseph F.,Grimsby, Joseph,Sarabu, Ramakanth

supporting information; experimental part, p. 3618 - 3625 (2010/07/05)

Glucokinase (GK) is a glucose sensor that couples glucose metabolism to insulin release. The important role of GK in maintaining glucose homeostasis is illustrated in patients with GK mutations. In this publication, identification of the hit molecule 1 and its SAR development, which led to the discovery of potent allosteric GK activators 9a and 21a, is described. Compound 21a (RO0281675) was used to validate the clinical relevance of targeting GK to treat type 2 diabetes.

SUBSTITUTED (THIAZOL-2-YL) -AMIDE OR SULFONAMIDE AS GLYCOKINASE ACTIVATORS USEFUL IN THE TREATMENT OF TYPE 2 DIABETES

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Page 32, (2010/02/07)

Compounds of the formula (I) provide pharmacological agents which are glucokinase activators and thus may be employed for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (I) may be employed for prevention and treatm

Heteroaromatic glucokinase activators

-

, (2008/06/13)

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

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