300386-87-2 Usage
Uses
Used in Pharmaceutical Industry:
(5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid is used as an analgesic for its ability to reduce pain, making it suitable for treating various types of discomfort and aches.
(5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid is used as an antipyretic to lower fever, helping to regulate body temperature in cases of elevated heat due to illness or other causes.
(5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid is used as an anti-inflammatory agent to alleviate inflammation, which is beneficial for conditions such as arthritis and other inflammatory disorders.
Used in Cardiovascular Health Applications:
(5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid is used as an antiplatelet agent to prevent blood clots, which can help in reducing the risk of heart attacks and strokes by promoting better blood flow.
These applications highlight the multifaceted utility of (5beta,7alpha,12alpha)-7,12-Bis(acetyloxy)-3-oxocholan-24-oic acid, or aspirin, in both the treatment of common ailments and more serious health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 300386-87-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,3,8 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 300386-87:
(8*3)+(7*0)+(6*0)+(5*3)+(4*8)+(3*6)+(2*8)+(1*7)=112
112 % 10 = 2
So 300386-87-2 is a valid CAS Registry Number.
300386-87-2Relevant academic research and scientific papers
Opsenica,Pocsfalvi,Juranic,Tinant,Declercq,Kyle,Milhous,Solaja
, p. 3274 - 3282 (2000)
Cholic acid-derived 1,2,4,5-tetraoxanes were synthesized in order to explore the influence of steroid carrier on its antimalarial and antiproliferative activity in vitro. Starting with chiral ketones, cis and trans series of diastereomeric tetraoxanes were obtained, and the cis series was found to be ~2 times as active as the trans against Plasmodium falciparum D6 and W2 clones. The same tendency was observed against human melanoma (Fem-X) and human cervix carcinoma (HeLa) cell lines. The amide C(24) termini, for the first time introduced into the carrier molecule of a tetraoxane pharmacophore, significantly enhanced both antimalarial and antiproliferative activity, as compared to the corresponding methyl esters, with cis-bis(N-propylamide) being most efficient against the chloroquine-susceptible D6 clone (IC50 = 9.29 nM). cis- and trans-bis(N-propylamides) were also screened against PBMC, and PHA-stimulated PBMC, showing a cytotoxicity/antimalarial potency ratio of 1/10 000.
