30039-20-4Relevant academic research and scientific papers
Hydroxysulfenylation of electron-deficient alkenes through an aerobic copper catalysis
Xi, Hui,Deng, Bicheng,Zong, Zhenzhen,Lu, Shenglin,Li, Zhiping
supporting information, p. 1180 - 1183 (2015/03/14)
A copper-catalyzed hydroxysulfenylation of α,β-unsaturated esters/amides is reported. The method presents a selective and efficient synthesis of β-hydroxysulfides bearing electron-withdrawing groups. The synthetic utility of this method is demonstrated by the concise synthesis of the anticancer drug bicalutamide.
Rongalite and base-promoted cleavage of disulfides and subsequent Michael addition to α,β-unsaturated ketones/esters: an odorless synthesis of β-sulfido carbonyl compounds
Guo, Wenxue,Lv, Guangshu,Chen, Jiuxi,Gao, Wenxia,Ding, Jinchang,Wu, Huayue
supporting information; experimental part, p. 2297 - 2300 (2010/06/16)
A highly practical method to access β-sulfido carbonyl compounds was developed, which could be conducted without any expensive reagent, special apparatus/technique, and no requirement of metal catalysts. β-Sulfido carbonyl compounds were formed at room temperature, in short time and with high chemoselectivity in good to excellent yields. A plausible mechanism for the role of Rongalite, as a promoter for the cleavage of disulfides generating thiolate anions that then undergo facile thia-Michael addition to α,β-unsaturated ketones and esters is proposed.
A novel synthesis of β-arylthio propanoic esters promoted by low- valent titanium
Shi, Daqing,Lu, Zaisheng,Mu, Lailong,Dai, Guiyuan
, p. 1073 - 1078 (2007/10/03)
Promoted by low-valent titanium, aryl sulfonyl chlorides react with α,β-unsaturated esters in THF to give β-arylthio propanoic esters in moderate to good yields.
