300586-90-7 Usage
Uses
Used in iPSC Reprogramming:
Benzamide, N-1H-pyrrolo[2,3-c]pyridin-5-ylis used as an enhancer for iPSC reprogramming efficiency. It increases the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in feeder cell-containing ESC media or in feeder-/serum-free iSF1 media. Benzamide, N-1H-pyrrolo[2,3-c]pyridin-5-ylworks by increasing cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels, which are crucial for the reprogramming process.
Used in Cellular Research:
Benzamide, N-1H-pyrrolo[2,3-c]pyridin-5-ylis used as a research tool for studying the mechanisms underlying iPSC reprogramming. It can help researchers understand how the compound increases mRNA levels of key transcription factors and how it may affect other cellular processes, such as Oct4 promoter methylation, Wnt signaling, and the expression of p53 and p21 mRNA levels.
Used in Pharmaceutical Development:
Benzamide, N-1H-pyrrolo[2,3-c]pyridin-5-ylmay be used as a starting point for the development of new pharmaceuticals targeting iPSC reprogramming and related cellular processes. Its ability to enhance iPSC reprogramming efficiency and modulate mRNA levels of key transcription factors could potentially be harnessed for therapeutic applications in regenerative medicine and other areas.
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 300586-90-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,5,8 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 300586-90:
(8*3)+(7*0)+(6*0)+(5*5)+(4*8)+(3*6)+(2*9)+(1*0)=117
117 % 10 = 7
So 300586-90-7 is a valid CAS Registry Number.
