300587-72-8

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 105-45-3 acetoacetic acid methyl ester 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Organocatalytic mediated green approach: A versatile new L-valine promoted synthesis of diverse and densely functionalized 2-amino-3-cyano-4H-pyrans

The discovery of a new L-valine promoted facile and versatile green synthesis of diversified 2-amino-3-cyano-4H-pyrans using a one pot multicomponent-tandem reaction of aromatic aldehydes, malononitrile, and diverse electron-rich enolizable carbonyl compo

Green synthesis and antibacterial, antifungal activities of 4H-pyran, tetrahydro-4H-chromenes and spiro2-oxindole derivatives by highly efficient Fe3O4@SiO2@NH2@Pd(OCOCH3)2 nanocatalyst

An efficiently, magnetically retrievable Fe3O4@SiO2@NH2@Pd(OCOCH3)2 nanoparticles was successfully synthesized and affirmed by several physicochemical characterization tools, such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-disoersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), and power X-ray diffraction. Thereafter, the catalytic performance of this environmentally benign nanocatalyst was investigated in the one-pot multicomponent synthesis of biologically important 2-amino-3-cyano-4H-pyran, tetrahydro-4H-chromenes and spiro2-oxindole derivatives. The reaction was simply achieved via one-pot three-component reaction of arylaldehydes, malononitrile and dimedone/isatins/methylaceto acetate ethanol at room temperature, with excellent yields and high purity. A new catalytic system, recyclability of reaction medium, little reaction times and excellent yields with easy workup render this protocol more attractive and economically viable.

DABCO catalyzed green and efficient synthesis of 2-Amino-4H-Pyrans and their biological evaluation as antimicrobial and anticancer agents

Aim and Objective: The present method is simple, green and highly efficient for the synthesis of 2-amino-4H-pyran derivatives which are achieved by a one pot three component cyclocondensation of aldehyde, malanonitrile and ethyl acetoacetate or methyl acetoacetate using DABCO under solvent free with grinding conditions at room temperature. Material and Methods: Some of the synthesized compounds were screened for their antimicrobial and antifungal activity. The study shows that these compounds show good antimicrobial activity. Furthermore, eight of the synthesized compounds were selected for screening of their anticancer activity against human astrocytoma-glioblastoma cell line (U373MG). Some of the compounds show good anticancer activity. Result: Grinding synthesis of 2-amino-4H-pyran derivatives catalyzed by DABCO with various aromatic aldehydes under solvent-free conditions at room temperature was examined. The obtained compounds (22 entries) were well synthesized in good to excellent yields. Conclusion: The present method is simple, rapid, and most efficient green protocol for the synthesis of 2-amino-4H-pyran derivatives using highly inexpensive and easily available DABCO as an efficient catalyst under grinding and solvent free condition at room temperature.

Amine-functionalized hyper-crosslinked polyphenanthrene as a metal-free catalyst for the synthesis of 2-amino-tetrahydro-4H-chromene and pyran derivatives

The hyper-crosslinked microporous polyphenanthrene spheres were fabricated simply by the polymerization of phenanthrene using bromomethyl methyl ether as a bridging agent in the absence of any templates. The organic spheres were subjected to amine-functionalizing on the periphery of them using unreacted bromomethyl groups. The amine-functionalized microporous polyphenthrene could be employed as a highly effective and stable solid basic catalyst for the syntheses of functionalized 2-amino-tetrahydro-4H-chromene and pyran derivatives. The significant features of these reactions are high product yields, environmental benignity, short reaction time, broad substrate scope, and non-requirement of toxic solvents. Furthermore, the catalyst can be reused up to four times without significant loss of activity.

Base free synthesis of iron oxide supported on boron nitride for the construction of highly functionalized pyrans and spirooxindoles

Boron nitride supported iron oxide (BN@Fe3O4) network was achieved via chemical reduction followed by aerial oxidation in absence of base. The prepared BN@Fe3O4 was characterized by powder XRD, FT-IR, Raman, BET and FE-SEM. The catalytic property was subsequently investigated for one-pot multicomponent domino reaction for the synthesis of highly functionalized pyrans and spirooxindoles derivatives on water. The present method is simple, high yielding, recyclable and requires no column chromatography.

Dibutylamine-catalysed efficient one-pot synthesis of biologically potent pyrans

An expedient, eco-friendly and efficient procedure for the preparation of novel pyran derivatives has been developed through a solvent-free, one-pot reaction of various aldehydes, malononitrile and either methylacetoacetate or ethyl benzoylacetate in the presence of dibutylamine (2.5 mol %) at room temperature. This procedure is advantageous because it is mild, environmentally friendly, gives high yields and requires short reaction times. Furthermore, the product did not necessitate separation via extraction and column chromatography.

Multicomponent domino reactions: Borax catalyzed synthesis of highly functionalised pyran-annulated heterocycles

A collection of pyrano[3,2-c] chromene, 4H-chromene and 4H-pyran were synthesized in excellent yield employing an innocuous, inexpensive and naturally occurring borax-catalyzed multicomponent domino reaction. The present protocol offers advantages in terms of higher yields, short reactions time and no workup and no column chromatography. The Royal Society of Chemistry 2013.

Microwave promoted, sodium acetate catalyzed one pot synthesis of poly functionalized 4H-pyrans

A clean and efficient one pot synthesis of 4H-pyran derivatives through condensation of aromatic aldehydes, malononitrile and dicarbonyl compounds under microwave irradiation in presence of Sodium acetate as a catalyst is described.