30060-12-9

Upstream product

• 610-71-9 2,5-dibromobenzoic acid 

Downstream Products

• 58580-09-9 5-bromo-2,3-phenylenediamine carboxylic acid 
• 1346574-57-9 GSK-126 
• 1346574-54-6 (S)-6-bromo-1-(sec-butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1H-indole-4-carboxamide 

Relevant academic research and scientific papers

New method for synthesis of EZH2 methyltransferase inhibitor GSK126

GSK126 is a potent small-molecule inhibitor of S-adenosyl-methionine-competitive EZH2 methyltransferase and has the potential to be used clinically for preventing unwanted histone methylation of tumor suppressor genes. In this article, we describe a new s

Method for synthesizing EZH2 methyltransferase inhibitor GSK126

The invention relates to a method for synthesizing an EZH2 methyltransferase inhibitor GSK126, and belongs to the field of medicinal chemistry. EZH2 is highly expressed in various malignant tumors and is expected to provide a new target for tumor therapy;