30062-49-8

Basic information

• Product Name: 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE
• Synonyms: 5-Propylsulfanyl-[1,3,4]thiadiazol-2-ylamine;2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE;1,3,4-thiadiazol-2-amine, 5-(propylthio)-;[5-(propylthio)-1,3,4-thiadiazol-2-yl]amine;1,3,4-Thiadiazole, 2-amino-5-(propylthio)-
• CAS NO: 30062-49-8
• Molecular Formula: C₅H₉N₃S₂
• Molecular Weight: 175.28
• Mol File: 30062-49-8.mol
• Article Data: 14

Chemical Properties

• Melting Point: 117-119 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 330.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 2.70±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE(30062-49-8)
• EPA Substance Registry System: 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE(30062-49-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 30062-49-8(Hazardous Substances Data)

Usage

General Description

2-Amino-5-N-propylthio-1,3,4-thiadiazole is a chemical compound with the molecular formula C5H10N4S2. It is a heterocyclic organic compound belonging to the thiadiazole class. 2-AMINO-5-N-PROPYLTHIO-1,3,4-THIADIAZOLE contains an amino group and a propylthio group attached to the thiadiazole ring. It has potential applications in the pharmaceutical and agricultural industries, as it may possess various biological activities such as antimicrobial, antiviral, and antifungal properties. However, further research is needed to fully understand its potential uses and effects.

Upstream product

• 107-03-9 1-thiopropane 
• 2349-67-9 2-Amino-5-mercapto-1,3,4-thiadiazole 
• 107-08-4 1-iodo-propane 
• 540-54-5 1-Chloropropane 
• 106-94-5 propyl bromide 

Downstream Products

• 54508-81-5 (5-propylsulfanyl-[1,3,4]thiadiazol-2-yl)-dithiocarbamic acid benzyl ester 
• 1309650-78-9 4-(4-chlorobenzoyl)-3-hydroxy-5-(4-nitrophenyl)-1-(5-(propylthio)-1,3,4-thiadiazol-2-yl)-1H-pyrrol-2(5H)-one 
• 1309650-79-0 5-(4-chlorophenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-(5-(propylthio)-1,3,4-thiadiazol-2-yl)-1H-pyrrol-2(5H)-one 
• 1309650-77-8 4-(4-chlorobenzoyl)-5-(4-chlorophenyl)-3-hydroxy-1-(5-(propylthio)-1,3,4-thiadiazol-2-yl)-1H-pyrrol-2(5H)-one 
• 1408325-11-0 C₂₇H₃₇N₃OS₃ 

Relevant articles and documents

Optimization of 1,3-disubstituted urea-based inhibitors of Zika virus infection

Zika virus (ZIKV) has become a public health concern worldwide due to its association with congenital abnormalities and neurological diseases. To date, no effective vaccines or antiviral drugs have been approved for the treatment of ZIKV infection, and ne

Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors

Importance of extracellular nucleotides is widely understood. These nucleotides act as ligand for P2X and P2Y receptors and modulate a variety of biological functions. However, their extracellular concentration is maintained by a chain of enzymes termed as ecto-nucleotidases. Amongst them, nucleoside triphosphate diphosphohydrolases (NTPDases) is an important enzyme family responsible for the dephosphorylation of these nucleotides. Overexpression of NTPDases leads to many pathological conditions such as cancer and thrombosis. So far, only a few NTPDase inhibitors have been reported. Considering this scarcity of (NTPDase) inhibitors, a number of thiadiazole amide derivatives were synthesized and screened against human (h)-NTPDases. Several compounds showed promising inhibitory activity; compound 5a (IC50 (μM); 0.05 ± 0.008) and 5g (IC50 (μM); 0.04 ± 0.006) appeared to be the most distinguished molecules corresponding to h-NTPDase1 and -2. However, h-NTPDase3 was the least susceptible isozyme and only three compounds (5d, 5e, 5j) strongly inhibited h-NTPDase3. Interestingly, compound 5e was recognized as the most active compound that showed dual inhibition against h-NTPDase3 as well as against h-NTPDase8. For better comprehension of binding mode of these inhibitors, most potent inhibitors were docked with their respective isozyme.

Design and development of 1,3,4-thiadiazole based potent new nano-fungicides

Being the important organic reaction intermediates and biological scaffolds, a series of 2-alkyl/aralkyl/heterocyclyl sulfanyl-5-amino/methyl-1,3,4-thiadiazoles have been synthesized by suitable synthetic route and characterized by analytical and spectral data. The evaluation of these compounds for their bioefficacy against two phyto-pathogenic fungi revealed their fungicidal potency against Rhizoctonia bataticola (ED50 values, 3.9–300.4 μg/mL) and Rhizoctonia solani (ED50 values, 4.2–228.5 μg/mL). To further augment their fungicidal efficacy, the potent five fungicidal compounds were nano-sized. The protocol for preparing 1,3,4-thiadiazole based nano-fungicide employing polyethylene glycol was developed and standardized. Characterization of nano-forms of 1,3,4-thiadiazole derivatives by particle size analyzer and electron microscopy (TEM) techniques confirmed the 100 nm average particle sizes of all nano-fungicides. The 2–4 times higher fungicidal activity was observed with nano-forms than the corresponding conventional sized 1,3,4-thiadiazole derivatives against phytopathogenic fungi, namely, Rhizoctonia solani and R. bataticola.