30065-34-0Relevant academic research and scientific papers
Synthesis of Some Novel Benzimidazole Derivatives as Anticancer Agent and Evaluation for CDK2 Inhibition Activity
El-Hameed, Rania Helmy Abd,Fatahala, Samar Said,Sayed, Amira Ibrahim
, p. 238 - 248 (2022/02/10)
Background: Thiobezimidazoles reveal various pharmacological activities due to similarities with many natural and synthetic molecules; they can easily interact with biomolecules of living systems. Objective: A series of substituted 2-thiobezimidazoles have been synthesized. Twelve final compounds were screened for in vitro anti-cancer activities against sixty different cell lines. Methods: The spectral data of the synthesized compounds were characterized. A docking study for active anticancer compounds and CDK2/CyclinA2 Kinase assay against standard reference; Imatinib, were performed. Results: Two compounds (3c&3l) from the examined series revealed effective antitumor activity in vitro against two-cancer cell lines (Colon Cancer (HCT-116) and Renal Cancer (TK-10). The docking study of synthesized molecules discovered a requisite binding pose in the CDK-ATP binding pocket .3c &3l were promoted in the CDK2/CyclinA2 Kinase assay against standard reference Imatinib. Conclusion: Against all tested compounds; two compounds 3c &3l were found active against two types of cell-lines.
Spectroscopic behavior, FMO, NLO and substitution effect of 2-(1H-Benzo[d]imidazole-2-ylthio)-N-o-substituted-acetamides: Experimental and theoretical approach
Arif, Ali Muhammad,Yousaf,Xu, Hong-liang,Su, Zhong-Min
, (2019/07/31)
The benzimidazole-based derivatives 2a-c were designed and synthesized via C–N coupling reaction and experimentally characterized by infrared spectroscopy (FT-IR), nuclear magnetic resonance (1H NMR) spectroscopy and mass spectrometry (MS). The
Synthesis and CNS Activity of 2-(N-Arylaminoacetylmercapto)- and 2-(N-Arylacetamidomercapto)-benzimidazoles
Tripathi, Shephali,Ahmad, Shakeel,Barthwal, J. P.,Kishor, K.,Tangri, K. K.,Bhargava, K. P.
, p. 379 - 380 (2007/10/02)
The title mercaptobenzimidazoles (1a-t) have been synthesised and screened for their anticonvulsant and monoamine oxidase (MAO) inhibitory activities.Some of the compounds provide 80percent protection against pentylenetetrazole-induced convulsions and max
