300660-86-0Relevant academic research and scientific papers
Location effect of an OH group on the chemiluminescence efficiency of 4-hydroperoxy-2-(o-, m-, or p-hydroxyphenyl)-4,5-diphenyl-4H-isoimidazoles
Tsunenaga, Mitsuru,Iga, Hiroshi,Kimura, Masaru
, p. 1877 - 1880 (2005)
In studying the location effect of an OH group on the chemiluminescence efficiency of 4-hydroperoxy-2-(o-, m-, or p-hydroxyphenyl)-4,5-diphenyl-4H- isoimidazoles 4, we found that the efficiency of 4a with o-OH was 0.28 times that of lophine peroxide on initiation with KOH/MeOH. When the trigger base was changed to TBAF/THF, efficiency was 530-fold in dry DMF. The efficiency of 4b with m-OH or 4c with p-OH showed no such dramatic change.
Heat- or singlet oxygen-generating agents and cancer treatment compositions comprising organic peroxide or chemiluminescent compound
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Page/Page column 7, (2008/06/13)
The present invention provides a heat-generating agent or singlet oxygen-generating agent effective as a new cancer treatment agent which, unlike an anticancer agent based on an alkylating agent such as MMC, uses the action of heat and/or singlet oxygen to kill cancer cells and reduce the burden on patients. A heat- and/or singlet oxygen-generating agent or a cancer treatment agent, comprising an organic peroxide such as the peroxide of an imidazole derivative or a chemiluminescent compound such as a dioxetane compound.
