30067-11-9

Upstream product

• 94-99-5 2,4-Dichlorobenzyl chloride 
• 68-12-2 N,N-dimethyl-formamide 
• 81156-68-5 2,4-dichlorophenylethyl alcohol 
• 55954-23-9 methyl 2-(2,4-dichlorophenyl)acetate 

Downstream Products

• 1580465-96-8 N¹-(2,4-dichlorophenethyl)-N³,N³-dimethylpropane-1,3-diamine 
• 1188446-70-9 ethyl 4-(2,4-dichlorophenyl)isoxazole-3-carboxylate 
• 431948-25-3 (E)-4-[2-(2,4-dichlorophenyl)ethenyl]morpholine 
• 172321-34-5 2-(2,4-dichlorobenzyl)-4,5-diphenylimidazole 
• 1345673-42-8 2-acetamido-N-tert-butyl-2-(3-(2,4-dichlorophenethylamino)propyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexanamide 
• 292601-09-3 2,4-dichlorophenylacetaldehyde N,N-dimethylhydrazone 

Relevant academic research and scientific papers

HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of GPR119 for the treatment or prevention of metabolic, cardiovascular, and metabolic diseases.

DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS

Inhibitors of HCV replication of formula (I) and the stereoisomers, prodrugs, tautomers, racemics, salts, hydrates or solvates thereof, wherein X, Y, R1; R2; R3; R4a and R4b have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.

Design and biological evaluation of phenyl-substituted analogs of β-phenylethylidenehydrazine

β-Phenylethylidenehydrazine (PEH) has been demonstrated previously to be an inhibitor of γ-aminobutyric acid transaminase (GABA-T) and to cause a marked increase in rat brain levels of GABA, a major neurotransmitter. A group of PEH analogs, possessing a variety of substituents (Me, OMe, Cl, F, and CF3) at the 2-, 3-, and 4-positions of the phenyl ring, were synthesized for evaluation as inhibitors of GABA-T. The details of the synthesis and chemical characterization of the analogs are described. Preliminary in vitro screening for GABA-T inhibition showed that all the analogs possessed activity against this enzyme, although substitution of CF3 at the 2- and 4-positions caused reduced activity. One of the drugs, 4-fluoro-β- phenylethylidenehydrazine, was investigated further ex vivo, where it was shown to inhibit GABA-T, elevate brain levels of GABA, and decrease levels of glutamine, similar to the profile observed previously for PEH.

Nitrogen-heterocyclic compound and process for production thereof

A nitrogen-heterocyclic compound is provided which is represented by General Formula (1): where R1and R2are independently hydrogen, an alkyl group, an aryl group, or a heteroaryl group; R3is hydrogen or an aryl group; Rsu