300696-53-1Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study
Elmenier, Fatma M.,Lasheen, Deena S.,Abouzid, Khaled A. M.
, p. 315 - 332 (2022/01/04)
Cancer is one of the most aggressive diseases characterised by abnormal growth and uncontrolled cell division. PI3K is a lipid kinase involved in cancer progression which makes it fruitful target for cancer control. 28 new morpholine based thieno[2,3-d] p
Antihelminthic activity of some 2-substituted thieno[2,3-d]pyrimidin-4-ones
Mavrova, Anelia,Dimov, Stefan,Vuchev, Dimitar,Anichina, Kameliya,Yancheva, Denitsa
, p. 887 - 894 (2018/07/03)
Background: One of the successful approaches for rational design of bioactive compounds is the bioisosterism strategy. Thus, the bioisosteric relation of thieno[2,3-d]pyrimidin-4-ones with quinazolines, cytosine and uracil resulted in the generation of co
Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives
Abbas, Safinaz E.,Abdel Gawad, Nagwa M.,George, Riham F.,Akar, Yahya A.
, p. 195 - 204 (2013/10/01)
Two series of new tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines namely 2,3-disubstituted derivatives 3a-z and 2,4-disubstituted ones 6a-c were prepared and tested for their antitumor and antibacterial activities. The structures of the prepared compounds we
Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one- based analogs
Wang, Yanong D.,Johnson, Steven,Powell, Dennis,McGinnis, John P.,Miranda, Miriam,Rabindran, Sridhar K.
, p. 3763 - 3766 (2007/10/03)
On the basis of a screening lead from an assay using a pair of p21 isogenic cell lines (p21-proficient cells and p21-deficient cells) to identify chemoselective agents, a series of novel thieno[2,3-d]pyrimidin-4(1H)-one-based analogs was prepared. Some an
