300706-95-0

Basic information

• Product Name: (1-allyl-1H-benzoimidazol-2-yl)methanol
• Synonyms: (1-allyl-1H-benzoimidazol-2-yl)methanol;1H-Benzimidazole-2-methanol,1-(2-propenyl)-(9CI);(1-allyl-1H-benzo[d]imidazol-2-yl)methanol
• CAS NO: 300706-95-0
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.22578
• Product Categories: BENZIMIDAZOLE
• Mol File: 300706-95-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-allyl-1H-benzoimidazol-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-allyl-1H-benzoimidazol-2-yl)methanol(300706-95-0)
• EPA Substance Registry System: (1-allyl-1H-benzoimidazol-2-yl)methanol(300706-95-0)

Safety Data

• Hazardous Substances Data: 300706-95-0(Hazardous Substances Data)

Usage

General Description

(1-allyl-1H-benzoimidazol-2-yl)methanol is a chemical compound that belongs to the class of benzoimidazole derivatives. It is a white to off-white solid that is soluble in organic solvents such as ethanol and acetone. (1-allyl-1H-benzoimidazol-2-yl)methanol has been studied for its potential pharmaceutical applications, particularly in the field of antifungal and antibacterial agents. It has also been investigated for its potential use as a corrosion inhibitor. Its chemical structure and functional groups make it a versatile compound with potential applications in various industries. However, further research is needed to fully understand and harness its potential uses.

Upstream product

• 4856-97-7 2-(Hydroxymethyl)benzimidazole 
• 55899-43-9 N-allyl-1,2-phenylenediamine 
• 95-54-5 1,2-diamino-benzene 
• 64266-27-9 3-(2-Hydroxymethyl-benzoimidazol-1-yl)-propionitrile 
• 106-95-6 allyl bromide 

Relevant articles and documents

Synthesis of pyrrolo- and pyrido-[1,2-α]benzimidazolequinone anti-tumor agents containing a fused cyclopropane ring

A cyclopropane ring has been fused onto tetrahydropyrrolo- and tetrahydropyrido-[1,2-a]-benzimidazoles and -benzimidazolequinones via the cycloaddition of diazomethines generated from the thermolysis of N-(allyl and but-3-enyl)benzimidazole-2-Eschenmoser hydrazones (aziridinyl imines). At lower temperatures, the 1,3-dipolar [3 + 2] cycloadduct was obtained for only the N-allylbenzimidazole-2-Eschenmoser hydrazones.

Design, synthesis, and biological evaluation of novel thiazolidinediones as PPAR3/FFAR1 dual agonists

Diabetes mellitus is a chronic metabolic disorder that affects more than 180 million people worldwide. Peroxisome proliferator activated receptors (PPARs) are a group of nuclear receptors that have been targeted by the thiazolidinedione (TZD) class of compounds for the management of type II diabetes. PPAR3 is known to regulate adipogenesis and glucose metabolism. Another emerging target for the design of antidiabetic agents is the free fatty acid receptor 1 (FFAR1), previously known as GPR40. Agonists of this receptor were found to enhance insulin secretion in diabetic patients. It has been reported that some thiazolidinediones (TZDs) activate FFAR1 with micromolar potency. In this study, based on docking studies into the crystal structure of PPAR3 and a homology model of FFAR1, nineteen compounds were designed, synthesized, and biologically tested for agonistic activity on both receptors. Nine compounds showed promising dual activity, with two compounds, 11a and 5b, having affinities in the low micromolar range on both targets. These molecules represent the first antidiabetic agents that could act as insulin sensitizers as well as insulin secretagogues.

Chemokine receptor binding heterocyclic compounds with enhanced efficacy

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).