300767-59-3

Basic information

• Product Name: 2-[(Z)-2-(benzylmethylcarbamoyl)vinyl]-5-methoxyphenyl acetate
• Synonyms: 2-[(Z)-2-(benzylmethylcarbamoyl)vinyl]-5-methoxyphenyl acetate
• CAS NO: 300767-59-3
• Molecular Weight: 339.391
• Mol File: 300767-59-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(Z)-2-(benzylmethylcarbamoyl)vinyl]-5-methoxyphenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(Z)-2-(benzylmethylcarbamoyl)vinyl]-5-methoxyphenyl acetate(300767-59-3)
• EPA Substance Registry System: 2-[(Z)-2-(benzylmethylcarbamoyl)vinyl]-5-methoxyphenyl acetate(300767-59-3)

Safety Data

• Hazardous Substances Data: 300767-59-3(Hazardous Substances Data)

Upstream product

• 300767-55-9 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-5-methoxyphenyl acetate 
• 300767-54-8 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-5-methoxyphenol 
• 300767-56-0 2-[(Z)-3-hydroxy-1-propenyl]-5-methoxyphenyl acetate 
• 300767-57-1 5-methoxy-2-[(Z)-3-oxo-1-propenyl]phenyl acetate 
• 300767-53-7 2-[(Z)-3-hydroxy-1-propenyl]-5-methoxyphenol 
• 531-59-9 7-methoxycoumarin 
• 103-67-3 benzyl-methyl-amine 
• 300767-58-2 (Z)-3-[2-(acetyloxy)-4-methoxyphenyl]acrylic acid 

Downstream Products

• 531-59-9 7-methoxycoumarin 
• 103-67-3 benzyl-methyl-amine 

Relevant articles and documents

The effect of phenyl substituents on the release rates of esterase-sensitive coumarin-based prodrugs

A coumarin-based prodrug system has been recently developed in our laboratory for the preparation of esterase-sensitive prodrugs of amines, peptides, and peptidomimetics. The drug release rates from this prodrug system were found to be dependent on the structural features of the drug moiety. In certain cases, the release can be undesirably slow for drugs that are secondary amines with relatively high pK(a)'s. Aimed at finding ways to manipulate the release rates to suit the need of different drugs, we have examined the effect of the phenyl ring substitutions on the release kinetics of such prodrugs and found that appropriately positioned alkyl substituents on the phenyl ring could help to facilitate the release by as much as 16-fold. Therefore, introduction of alkyl substituents on the phenyl ring should allow us to manipulate the release rates and, therefore, time profiles for different drugs.