30077-81-7

Basic information

• Product Name: 3-morpholino-2-(3,4,5-trimethoxybenzyl)acrylonitrile
• Synonyms: 3-morpholino-2-(3,4,5-trimethoxybenzyl)acrylonitrile;3,4,5-Trimethoxy-α-(morpholinomethylene)benzenepropiononitrile
• CAS NO: 30077-81-7
• Molecular Formula: C₁₇H₂₂N₂O₄
• Molecular Weight: 318.36758
• EINECS: 250-030-5
• Mol File: 30077-81-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 492.2°Cat760mmHg
• Flash Point: 251.5°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 7.86E-10mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 3-morpholino-2-(3,4,5-trimethoxybenzyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-morpholino-2-(3,4,5-trimethoxybenzyl)acrylonitrile(30077-81-7)
• EPA Substance Registry System: 3-morpholino-2-(3,4,5-trimethoxybenzyl)acrylonitrile(30077-81-7)

Safety Data

• Hazardous Substances Data: 30077-81-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H22N2O4/c1-20-15-9-13(10-16(21-2)17(15)22-3)8-14(11-18)12-19-4-6-23-7-5-19/h9-10,12H,4-8H2,1-3H3/b14-12-

Upstream product

• 22630-09-7 trimorpholylmethane 
• 49621-50-3 3-(3,4,5-Trimethoxyphenyl)propionitrile 
• 4542-47-6 3-Morpholin-4-yl-propionitrile 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 738-70-5 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine 

Relevant articles and documents

Immobilization of malarial (Plasmodium falciparum) dihydrofolate reductase for the selection of tight-binding inhibitors from combinatorial library

A simple procedure for selection of tight-binding inhibitors of mutant dihydrofolate reductases from Plasmodium falciparum (PfDHFRs) based on preferential binding to the enzyme immobilized on a Sepharose column has been described. PfDHFRs with a cysteine residue at the C-terminal have been prepared in order to immobilize to a thiopropyl-Sepharose gel via S-S linkage. The amount of immobilized DHFRs was estimated to be 4-5 mg/g of dried gel, and the activities of bound DHFRs were comparable to that of free enzymes. The prepared immobilized enzyme has been used for the selection of tight-binding inhibitors from combinatorial libraries, based on the affinities of each ligand with the enzyme. Free ligands were then identified and analyzed quantitatively by high-performance liquid chromatography-mass spectrometry, and the components with high binding affinity of the library could thus be realized. Results could be confirmed by quantitative analysis of the bound ligands released from the enzyme by guanidine hydrochloride treatment.