300799-40-0Relevant academic research and scientific papers
Gypsum-catalyzed one-pot synthesis of 3,4-Dihydropyrimidin-2(1H)-ones under solvent-free conditions
Boumoud, Taoues,Boumoud, Boudjemaa,Mosset, Paul,Debache, Abdelmadjid
, p. 312 - 318 (2011)
In view of the emerging importance of the green chemistry principles in chemical and pharmaceutical industries, we disclose, herein, a new economic approach producing the biologically active dihydropyrimidinones in good yields using the solventless one-po
Reduction of Biginelli compounds by LiAlH4: a rapid access to molecular diversity
Zlatkovi?, Dragan B.,Radulovi?, Niko S.
, p. 115058 - 115067 (2016/12/24)
Herein, the reduction of Biginelli compounds by LiAlH4 was investigated for the first time. The reduction of urea-derived dihydropyrimidinones yielded 80-95% of hydrogenolysis products (4-aryl-5-(m)ethyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones
Improving the selectivity toward three-component biginelli versus hantzsch reactions by controlling the catalyst hydrophobic/hydrophilic surface balance
Karimi, Babak,Mobaraki, Akbar,Mirzaei, Hamid M.,Zareyee, Daryoush,Vali, Hojatollah
, p. 212 - 219 (2014/01/23)
The catalytic activities and selectivities of two kinds of mesoporous solid acids SBA-15-PrSO3H 1, SBA-15-Ph-PrSO3H 2, and a periodic mesoporous organosilica (PMO) based solid acid Et-PMO-Me-PrSO3H 3 that comprise differen
Hydrophobicity-enhanced magnetic solid sulfonic acid: A simple approach to improve the mass transfer of reaction partners on the surface of the heterogeneous catalyst in water-generating reactions
Mobaraki, Akbar,Movassagh, Barahman,Karimi, Babak
, p. 123 - 133 (2014/01/23)
Two novel and environmentally benign organosulfonic acid-functionalized silica-coated magnetic nanoparticle catalysts 1 (Fe3O 4@SiO2@Et-PhSO3H) and 2 (Fe3O 4@SiO2@Me&Et-PhSO3H) were prepared and their surface hydrophobicity was assessed by esterification reaction of fatty alcohols. Also, their water-toleration in two water-generating reactions was investigated, namely: synthesis of bis(indolyl)methane and the Biginelli reaction of benzaldehyde, methyl acetoacetate, and urea under solvent-free conditions. In these reactions, the catalyst 2 that was more hydrophobic and water-resistant showed higher catalytic activity and was characterized extensively by various techniques. This catalyst was successfully used in the Biginelli reaction of a series of aldehydes, β-keto esters, and urea/thiourea for the synthesis of a diverse range of pharmacologically active 3,4-dihydropyrimidin-2-one/thione (DHPM) derivatives. The catalyst 2 was easily separated by an external magnet and the recovered catalyst was reused in five cycles without any significant loss of activity.
A catalytic dual-activation approach to the significant 3,4-dihydropyrimidin-2(1H)-one system via the bignelli reaction
Boumoud, Boudjemaa,Mennana, Imène,Boumoud, Taoues,Debache, Abdelmadjid
, p. 8 - 11 (2013/07/26)
In many chemical processes, Lewis acids and bases are used to activate reactants simultaneously or sequentially. The integration of both Lewis base and Lewis acid has great potential to enhance known reactivity and drive the development of new chemical re
Acidic task-specific ionic liquid as catalyst of microwave-assisted solvent-free Biginelli reaction
Arfan,Paquin,Bazureau
, p. 1058 - 1064 (2008/09/16)
A simple and effective synthesis of 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidine-2(1H)-thione derivatives has been developed on the basis of three-component condensation of substituted aromatic and heterocyclic aldehydes, methyl acetoacetate,
