Basic information

Product Name: RS 102895
Synonyms: 1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE;RS 102895 HYDROCHLORIDE;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride
CAS NO:300815-41-2
Molecular Formula: C21H21F3N2O2.ClH
Molecular Weight: 426.864
EINECS: N/A
Product Categories: Cytokine signaling;RS 102895 CCR2-selective chemokine receptor antagonist.
Mol File: 300815-41-2.mol

Chemical Properties

Melting Point: N/A
Boiling Point: 446.1±45.0 °C(Predicted)
Flash Point: N/A
Appearance: /powder
Density: 1.33±0.1 g/cm3 (20 ºC 760 Torr)
Refractive Index: N/A
Storage Temp.: Desiccate at RT
Solubility: DMSO: 18 mg/mL, clear, colorless
PKA: 13.46±0.20(Predicted)
CAS DataBase Reference: RS 102895(CAS DataBase Reference)
NIST Chemistry Reference: RS 102895(300815-41-2)
EPA Substance Registry System: RS 102895(300815-41-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: 22-24/25
WGK Germany: 3
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 300815-41-2(Hazardous Substances Data)

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SDS
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300815-41-2 Usage

Uses

RS 102895 is a CCR2-selective chemokine receptor inhibitor.

Biological Activity

CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.

Check Digit Verification of cas no

The CAS Registry Mumber 300815-41-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,8,1 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 300815-41:
(8*3)+(7*0)+(6*0)+(5*8)+(4*1)+(3*5)+(2*4)+(1*1)=92
92 % 10 = 2
So 300815-41-2 is a valid CAS Registry Number.

300815-41-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name	1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride

1.2 Other means of identification

Product number	-
Other names	RS 102895 hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:300815-41-2 SDS

300815-41-2Upstream product

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