300817-68-9 Usage
Uses
Used in Cancer Therapy:
BH3I-1 is used as an apoptosis inducer for targeting Bcl-2 family proteins, which play a critical role in preventing cell death. By inhibiting the interactions between BH3 domain-containing proteins and Bcl-2 family members, BH3I-1 promotes apoptosis in Bcl-2 or Bcl-W expressing cells, making it a potential therapeutic agent for cancer treatment.
Used in Enhancing Radiation Sensitivity:
In the field of non-small cell lung cancer treatment, BH3I-1 is used as a radiosensitizer to enhance the effectiveness of radiation therapy. By increasing the sensitivity of cancer cells to radiation, BH3I-1 can improve treatment outcomes and potentially reduce the required dosage of radiation, thereby minimizing side effects and damage to healthy tissues.
Used in Drug Development:
BH3I-1 serves as a valuable compound in the development of new drugs targeting the Bcl-2 family of proteins. Its ability to inhibit protein-protein interactions and induce apoptosis makes it a promising candidate for the creation of novel therapeutics for various types of cancer.
Used in Research:
In the field of molecular biology and cell biology, BH3I-1 is used as a research tool to study the mechanisms of apoptosis and the role of Bcl-2 family proteins in cell death. BH3I-1 can help researchers gain a deeper understanding of the complex interactions between pro-apoptotic and anti-apoptotic proteins, ultimately contributing to the development of more effective cancer treatments.
in vitro
the bcl-2 inhibitors bh3i-1 and it analog bh3i-2 had been applied as lead compounds to find possible bcl-2 or bcl-x(l) inhibitors by using computer-assisted screening of in-house database. the identified compounds were further studied regarding their possible application as a drug. it was found that the induction of apoptosis, which was shown as number of hypodiploid cells, was increased by adding bh3i-1 and it analog bh3i-2 to bjab bcl-xl and bjab neo/mock cells. in addition, the effects of the pro-apoptotic proteins bax and bak on the induction of apoptosis via bh3i-1 and it analog bh3i-2 were investigated with a variety of knockout cell lines, and resulted showed that the presence or absence of bak or bax has no significant influence on the amount of apoptotic events induced by bh3i-1 and it analog bh3i-2 [1].
IC 50
293.95 μm
references
[1] füllbeck m,gebhardt n,hossbach j,daniel pt,preissner r. computer-assisted identification of small-molecule bcl-2 modulators. comput biol chem.2009 dec;33(6):451-6.
Check Digit Verification of cas no
The CAS Registry Mumber 300817-68-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,0,8,1 and 7 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 300817-68:
(8*3)+(7*0)+(6*0)+(5*8)+(4*1)+(3*7)+(2*6)+(1*8)=109
109 % 10 = 9
So 300817-68-9 is a valid CAS Registry Number.
