300840-28-2Relevant academic research and scientific papers
N-Sulfonyloxy-β-lactam inhibitors for β-lactamases
Bulychev, Alexey,Bellettini, John R.,O'Brien, Michael,Crocker, Peter J.,Samama, Jean-Pierre,Miller, Marvin J.,Mobashery, Shahriar
, p. 5719 - 5728 (2007/10/03)
Structure-function analysis with a series of N-sulfonyloxy β-lactam molecules as inhibitors of β-lactamases is reported. The best of these compounds acylate the active site of the class A TEM-1 β-lactamase from Escherichia coli rapidly, and resist deacylation. Whereas acylation of the active site of the class C β-lactamase from Enterobacter cloacae was not seen, these compounds function as competitive inhibitors of this enzyme. (C) 2000 Elsevier Science Ltd.
