300842-64-2

Basic information

• Product Name: N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
• Synonyms: N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine;Acc-789;ZK 202650;NVP-ACC-789;ACC-789 (NVP-ACC789);N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
• CAS NO: 300842-64-2
• Molecular Formula: C₂₁H₁₇BrN₄
• Molecular Weight: 405.29048
• Mol File: 300842-64-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 607.7°C at 760 mmHg
• Flash Point: 321.3°C
• Appearance: /
• Density: 1.441
• Vapor Pressure: 1.03E-14mmHg at 25°C
• Refractive Index: 1.707
• CAS DataBase Reference: N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine(300842-64-2)
• EPA Substance Registry System: N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine(300842-64-2)

Safety Data

• Hazardous Substances Data: 300842-64-2(Hazardous Substances Data)

Usage

Description

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, also known as NVP-ACC789, is a small molecule compound that acts as an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3, and PDGFR-β. It has IC50s of 0.38, 0.02 (0.23), 0.18, and 1.4 μM, respectively. N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine has potential applications in various industries due to its ability to inhibit these receptors.

Uses

Used in Pharmaceutical Industry:
NVP-ACC789 is used as a pharmaceutical agent for the treatment of various diseases, particularly cancer. Its ability to inhibit VEGFR and PDGFR-β receptors makes it a potential candidate for targeting angiogenesis and tumor growth.
Used in Cancer Research:
In cancer research, NVP-ACC789 is used as a research tool to study the role of VEGFR and PDGFR-β receptors in tumor growth and angiogenesis. It helps researchers understand the mechanisms of action and potential therapeutic effects of inhibiting these receptors in cancer cells.
Used in Drug Development:
NVP-ACC789 is used in drug development as a lead compound for the development of new drugs targeting VEGFR and PDGFR-β receptors. Its inhibitory properties make it a promising candidate for the development of targeted therapies for various diseases, including cancer.
Used in Diagnostic Imaging:
NVP-ACC789 can be used in diagnostic imaging as a contrast agent for visualizing tumors and other abnormalities in the body. Its ability to target VEGFR and PDGFR-β receptors can help in the detection and monitoring of diseases, particularly cancer.

InChI:InChI=1/C21H17BrN4/c1-14-6-7-16(13-19(14)22)24-21-18-5-3-2-4-17(18)20(25-26-21)12-15-8-10-23-11-9-15/h2-11,13H,12H2,1H3,(H,24,26)

Downstream Products

• 300843-34-9 [4-(3-brom-4-methyl-anilino)phthalazin-1-yl](pyridin-4-yl)methanol