300843-70-3

Basic information

• Product Name: C₉H₈N₂O
• Synonyms: C₉H₈N₂O
• CAS NO: 300843-70-3
• Molecular Weight: 160.175
• Mol File: 300843-70-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₉H₈N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₉H₈N₂O(300843-70-3)
• EPA Substance Registry System: C₉H₈N₂O(300843-70-3)

Safety Data

• Hazardous Substances Data: 300843-70-3(Hazardous Substances Data)

Upstream product

• 773837-37-9 sodium cyanide 
• 74635-18-0 N-benzylmethylene nitrone 
• 100-46-9 benzylamine 
• 3010-05-7 benzylaminoacetonitrile 

Downstream Products

• 622-30-0 N-benzyl hydroxylalmine 

Relevant articles and documents

Dynamics in Catalytic Asymmetric Diastereoconvergent (3 + 2) Cycloadditions with Isomerizable Nitrones and α-Keto Ester Enolates

Reaction design in asymmetric catalysis has traditionally been predicated on a structurally robust scaffold in both substrates and catalysts, to reduce the number of possible diastereomeric transition states. Herein, we present the stereochemical dynamics in the Ni(II)-catalyzed diastereoconvergent (3 + 2) cycloadditions of isomerizable nitrile-conjugated nitrones with α-keto ester enolates. Even in the presence of multiple equilibrating species, the catalytic protocol displays a wide substrate scope to access a range of CN-containing building blocks bearing adjacent stereocenters with high enantio- and diastereoselectivities. Our computational investigations suggest that the enantioselectivity is governed in the deprotonation process to form (Z)-Ni-enolates, while the unique syn addition is mainly controlled by weak noncovalent bonding interactions between the nitrone and ligand.

Transformation of primary amines to N-monoalkylhydroxylamines: N-hydroxy-(S)-1-phenylethylamine oxalate: [(Benzenemethanamine, N-hydroxy--methyl-, (S)-, ethanedioate)]

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