300853-91-2

Basic information

• Product Name: Pyrrolidine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-phenyl-1-(phenylmethyl )-, (3R,4S)-
• CAS NO: 300853-91-2
• Molecular Formula: C24H35NOSi
• Molecular Weight: 381.634
• Mol File: 300853-91-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-phenyl-1-(phenylmethyl )-, (3R,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-phenyl-1-(phenylmethyl )-, (3R,4S)-(300853-91-2)
• EPA Substance Registry System: Pyrrolidine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-4-phenyl-1-(phenylmethyl )-, (3R,4S)-(300853-91-2)

Safety Data

• Hazardous Substances Data: 300853-91-2(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 221141-87-3 [(3R,4S)-1-benzyl-4-phenylpyrrolidin-3-yl]methanol 
• 221141-86-2 (S)-4-Benzyl-3-((3R,4S)-1-benzyl-4-phenyl-pyrrolidine-3-carbonyl)-oxazolidin-2-one 
• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 128891-66-7 (4S)-4-benzyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one 

Downstream Products

• 361382-19-6 (3R,4S)-1-Benzenesulfonyl-4-phenyl-pyrrolidine-3-carbaldehyde 

Relevant articles and documents

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: Discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

A series of 1,3,4-trisubstituted pyrrolidines was discovered to have the ability to displace [125I]-MIP-1α from the CCR5 receptor expressed on Chinese hamster ovary (CHO) cell membranes. CCR5 activity was found to be dependent on the regiochemi