30086-17-0

Basic information

• Product Name: 4-FLUORO-1H-IMIDAZOLE
• Synonyms: 4-FLUORO-1H-IMIDAZOLE;4-Fluoro-1(3)H-imidazole;1H-Imidazole, 5-fluoro-;5-Fluoro-1H-imidazole;4-Fluoroimidazole;Nsc 208718;4-FI;4(5)-Fluoroimidazole
• CAS NO: 30086-17-0
• Molecular Formula: C₃H₃FN₂
• Molecular Weight: 86.0677232
• Product Categories: Heterocyclic Compounds;Heterocycles;Fluorinated heterocyclic series
• Mol File: 30086-17-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 101-1040C
• Boiling Point: 261 °C at 760 mmHg
• Flash Point: 111.7 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 0.0192mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• PKA: 12.42±0.10(Predicted)
• CAS DataBase Reference: 4-FLUORO-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-1H-IMIDAZOLE(30086-17-0)
• EPA Substance Registry System: 4-FLUORO-1H-IMIDAZOLE(30086-17-0)

Safety Data

• Hazardous Substances Data: 30086-17-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

4-Fluoro-1H-imidazole is an antiviral agent and inhibitor of polynucleotide biosynthesis.

InChI:InChI=1/C3H3FN2/c4-3-1-5-2-6-3/h1-2H,(H,5,6)

Upstream product

• 4919-03-3 4-amino-1H-imidazole 
• 78162-58-0 N,N-dimethyl-1H-imidazole-1-sulfonamide 
• 3034-38-6 1H-4⁽⁵⁾-nitroimidazole 

Downstream Products

• 1248592-26-8 methyl {2-[(4-fluoro-1H-imidazol-1-yl)methyl]phenyl}acetate 

Relevant articles and documents

Determination of inter-ionic and intra-ionic interactions in a monofluorinated imidazolium ionic liquid by a combination of X-ray crystallography and NOE NMR spectroscopy

We report the very first application of a Transient 1D 1H{19F} NOE NMR experiment in neat ionic liquids. In comparison with classical 2D HOESY NMR spectroscopy, a substantial reduction in measurement time is gained with comparable quality and information content of the spectra. In combination with classical X-ray crystallography, we have applied this technique for the determination of inter-ionic distances (i.e. probabilities of presence) utilizing an ionic liquid containing a monofluorinated imidazolium cation. Copyright

Photochemical decomposition of diazonium fluoroborates. Application to the synthesis of ring-fluorinated imidazoles.

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NOVEL COMPOUNDS

Disclosed are N-{[(1R,4S,6R)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and their use as pharmaceuticals.

Regio- and stereoselective glycosylation: Synthesis of 5-haloimidazole α-ribonucleosides

We describe the synthesis of novel 5-haloimidazole ribonucleosides as precursors of modified cobalamins. A regio- and stereoselective glycosylation of protected ribose with silylated 4(5)-haloimidazoles produces 5-haloimidazole ribonucleosides predominant