30096-07-2

Upstream product

• 72658-09-4 (E)-(1-methoxyprop-1-enyloxy)trimethylsilane 
• 98-95-3 nitrobenzene 
• 30095-98-8 methyl (2-nitrophenyl)acetate 
• 74-88-4 methyl iodide 
• 860786-10-3 dimethyl 2-methyl-2-(2-nitrophenyl)malonate 
• 26465-37-2 dimethyl 2-(2-nitrophenyl)malonate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 

Downstream Products

• 1504-06-9 3-methylindolin-2-one 
• 77656-96-3 2-(2-nitrophenyl)propanoic acid 
• 1316859-84-3 1-nitro-2-(1-phenylethyl)benzene 
• 1316859-85-4 1-nitro-2-(1-(4-(trifluoromethyl)phenyl)ethyl)benzene 
• 1316859-86-5 1-(1-(4-fluorophenyl)ethyl)-2-nitrobenzene 
• 1316859-87-6 1,3-dimethoxy-5-(1-(2-nitrophenyl)ethyl)benzene 
• 1316859-99-0 potassium 2-(2-nitrophenyl)propanoate 
• 1452823-85-6 1-(1-(cyclohex-1-en-1-yl)ethyl)-2-nitrobenzene 
• 1616854-57-9 tert-butyl 4-(2-(1-methoxy-1-oxopropan-2-yl)phenylamino)piperidine-1-carboxylate 
• 1616851-89-8 2-(1-(1-(3-(2-chloro-5-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide 
• 1616851-91-2 2-(1-(1-(3-(3-methoxyphenoxy)-4-methylpentyl)piperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide 
• 1616854-62-6 methyl 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)acetate 
• 1616851-48-9 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide 
• 1616854-64-8 2-(1-(1-benzylpiperidin-4-yl)-3-methyl-2-oxoindolin-3-yl)-N-methylacetamide 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure

Herein we report our efforts of developing reversible selective hMAO-B inhibitors based on isatin, a fragment in an X-ray crystal structure. Five different scaffolds were designed and many compounds were synthesized. Among them, compound A3 demonstrated very high potency and isoform selectivity against hMAO-B, 11 and 13 times more potent (IC50 = 3 nM) and 23.64 and 6.8 times more selective than the marked drugs, selegiline and safinamide. However, the endeavors to modify the polar 3-one group of isatin, that is in a hydrophobic environment in the binding site of hMAO-B, to small nonpolar hydrophobic groups did not bring about improved hMAO-B inhibitors, which may challenge our understanding of molecular interactions and molecular recognition in biological systems.

Synthesis of o-Aminophenols via a Formal Insertion Reaction of Arynes into Hydroxyindolinones

A novel approach toward the synthesis of sterically hindered o-aminophenols has been achieved by a formal aryne insertion into hydroxyindolinones. This transformation offers a rapid and efficient entry to diverse o-aminophenol scaffolds under mild transit

HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are heterocyclyl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Palladium-catalyzed decarboxylative vinylation of potassium nitrophenyl acetate: Application to the total synthesis of (±)-goniomitine

Merge and divert: The natural product (±)-goniomitine was synthesized by a method featuring two key steps: 1) fragment coupling to a functionalized cyclopentene by a novel palladium-catalyzed decarboxylative vinylation reaction and 2) an unprecedented one-pot integrated oxidation/reduction/cyclization (IORC) process to convert the substituted cyclopentene into the tetracyclic skeleton of goniomitine with high chemo-, regio-, and diastereoselectivity.

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.

Formal total synthesis of (-)-physostigmine

The formal total synthesis of (-)-physostigmine via the chiral malonic acid mono-ester ((R)-2-(2-chlorophenyl)-2-methoxycarbonylpropanoic acid, 99% ee) newly prepared by the pig liver esterase (PLE) mediated asymmetric hydrolysis of the corresponding di-e

Nucleophilic Addition of Silyl Enol Ethers to Aromatic Nitro Compounds: Scope and Mechanism of Reaction

In sharp contrast to alkali-metal enolates, silyl enol ethers and ketene silyl acetals add to aromatic nitro compounds in the presence of a fluoride ion source to give the intermediate dihydroaromatic nitronates, which can be observed by NMR.In situ oxidation of the intermediate with bromine or DDQ yields α-nitroaryl carbonyl compounds in moderate-to-high yields.The reaction is applicable to alkyl-, alkoxy-, and halogen-substituted nitrobenzenes as well as to heterocyclic and condensed nitroaromatic compounds.While substitution ortho to the nitro group predominates with sterically undemanding silyl reagents, para-substitution products are exclusively obtained with bulky reagents.However, by blocking the para position with an appropriate group such as chlorine, the addition can be directed to the ortho position.Halogen atoms of halogenated nitroaromatics and p-nitrocumenyl chloride are not displaced in the reaction, suggesting the absence of radical ion intermediates.Dihydroaromatic nitro derivatives ca be isolated in some cases, such as anthracene and naphthalene systems which are less prone to rearomatize.

Nucleophilic Addition of Silyl Enol Ethers to Aromatic Nitro Compounds: A Facile Synthesis of α-Nitroaryl Carbonyl Compounds

Silyl enol ethers and silyl ketene acetals add to aromatic nitro compounds in the presence of fluoride ion sources (e.g. tris(dimethylamino)sulfonium difluorotrimethylsiliconate (TASF)) to give, after oxidation, α-nitroaryl carbonyl compounds.