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301-12-2

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301-12-2 Usage

Description

Oxydemeton-methyl, i.e., demeton-S-methyl sulfoxide, is a colorless oil, bp 106 ?C/0.01 mm Hg, vp 3.8 mPa (20 ?C). It is miscible with water and soluble in most organic solvents, except petroleum ether. Log Kow = ?0.74(21 ?C). Oxydemeton-methyl is relatively stable in acidic media but hydrolyzed in alkalinemedia;DT50 values (22 ?C) at pH 4, 7, and 9 are 107, 46, and 2 d, respectively.

Chemical Properties

Oxydemeton methyl is a colorless to amber-colored liquid. Oxydemeton methyl is relatively slowly hydrolyzed in acidic media, but rapidly hydrolyzed in alkaline media. Oxydemeton methyl is miscible with water; readily soluble (10–100 g/ 100 mL) in dichloromethane, 2-propanol, and toluene; and practically insoluble (<1 g/100 mL) in n-hexane.

Uses

Different sources of media describe the Uses of 301-12-2 differently. You can refer to the following data:
1. Oxydemeton-methyl is used to control sucking insects on fruit, vines, vegetables, cereals and ornamentals.
2. Systemic and contact insecticide and acaricide used to control spider mites and other insects on vegetables and some ornamentals.

General Description

Clear amber liquid.

Air & Water Reactions

Water soluble. DEMETON-S-METHYL SULFOXIDE may be rapidly hydrolyzed by alkali .

Reactivity Profile

Organophosphates such as DEMETON-S-METHYL SULFOXIDE are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Fire Hazard

DEMETON-S-METHYL SULFOXIDE is flammable.

Safety Profile

Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of POx and SOx. See also other demeton entries.

Environmental Fate

Soil. The sulfoxide group is oxidized to the sulfone and oxidative and hydrolytic cleavage of the side chain gives dimethylphosphoric and phosphoric acids (Hartley and Kidd, 1987). Oxamyl was degraded by the microorganism Pseudomonas putida in a laboratory study using cultured bacteria (Zeigler, 1980).Plant. In asparagus, oxydemeton-methyl was converted to the corresponding sulfone (Szeto and Brown, 1982).Chemical/Physical. Oxydemeton-methyl can be converted to the corresponding sulfone by hydrogen peroxide (Cremlyn, 1991). Emits toxic fumes of phosphorus and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

Metabolic pathway

Oxydemeton-methyl is the primary thiooxidation metabolite of demeton- S-methyl. It is further oxidised rapidly to demeton-Smethylsulfon in all media. The major route of further metabolism of both sulfoxide and sulfone is via hydrolysis to the sulfoxide and sulfone thiols. Stage I1 metabolism of these thiol hydrolysis products proceeds via oxidation and conjugation and is different in soil, plants and animals. In plants the thiols are conjugated, whereas in animals they are mainly methylated and oxidised to sulfoxides, sulfones and sulfonic acids. Demethylation is an important route in mammals; however, the compound is sufficiently polar for much to be excreted in the urine unchanged. Demethylation has also been reported to occur in plants.

Metabolism

Almost 99% of orally administered oxydemeton-methyl to animals is excreted within 48 h in the urine. It is oxidized to the sulfone, followed by hydrolytic cleavage of the P?S bond. The thiol metabolites are conjugated or methylated. O-Demethylation is also an important degradation route both inmammals and plants. Oxydemeton-methyl is rapidly degraded in soils.

Toxicity evaluation

The acute oral LD50 for rats is about 50 mg/kg. Inhalation LC50 (4 h) for rats is 0.47 mg/L air. NOEL (2 yr) for rats is 1 mg/kg diet (0.05 mg/kg/d). ADI is 0.3 μg/kg b.w. for the sum of oxydemeton-methyl, demeton-S-methylsulfone, and demeton-S-methyl.

Degradation

Oxydemeton-methyl is relatively slowly hydrolysed in acidic media but rapidly hydrolysed under alkaline conditions. Half-lives at pH values 4,7 and 9 were 107,46 and 2 days respectively (PM). Under sterile aqueous conditions oxydemeton-methyl was degraded to give the oxidised hydrolysis product bis[2-(ethylsulfinyl)ethyl] disulfide (2) (Ziegler et al., 1980) (Scheme 1).

Check Digit Verification of cas no

The CAS Registry Mumber 301-12-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 301-12:
(5*3)+(4*0)+(3*1)+(2*1)+(1*2)=22
22 % 10 = 2
So 301-12-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H15O4PS2/c1-4-13(8)6-5-12-11(7,9-2)10-3/h4-6H2,1-3H3

301-12-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name oxydemeton-methyl

1.2 Other means of identification

Product number -
Other names Oxydemetonmethyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Insecticide
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:301-12-2 SDS

301-12-2Upstream product

301-12-2Relevant articles and documents

Selective Sulfur Oxygenation in Phosphoroamidate, Thionophosphate, and Thiophosphate Agrochemicals by Perfluoro-cis-2,3-dialkyloxaziridine

Terreni, Marco,Pregnolato, Massimo,Resnati, Giuseppe,Benfenati, Emilio

, p. 7981 - 7992 (2007/10/02)

Several organophsophorus agrochemicals 2a-g with thioether, phosphoramidic, phosphorothioic, and phosphorothionic functions were reacted with perfluoro-cis-2-n-butyl-3-n-propyloxaziridine 1.The selective oxygenation of sulfide function to give sulfoxide derivatives 3a-g occured in high yields without overoxidation to sulfone products.Sulfoxides 3a-e were further oxidized under mild conditions to the corresponding sulfones 4a-e.All the products are themselves of interest as analytical environmental standards and their preparation is described in detail.

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