3011-34-5Relevant articles and documents
Design, synthesis and nonlinear optical properties of (E)-1-(4-substituted)-3-(4-hydroxy-3-nitrophenyl) prop-2-en-1-one compounds
Saha, Amrita,Shukla, Vijay,Choudhury, Sudip,Jayabalan
, p. 184 - 189 (2016)
A new series of (E)-1-(4-substituted)-3-(4-hydroxy-3-nitrophenyl) prop-2-en-1-one compounds have been synthesized by Claisen-Schmidt condensation reaction. Nonlinear optical characterization were carried out using z-scan technique with nanosecond pulses. These samples are found to exhibit strong nonlinear absorption at 532 nm and the nonlinear absorption coefficient of these samples exponentially increases with the increase of phonon characteristic energy. This relation speaks the role of phonon in the origin of nonlinear absorption in these compounds. The reported dependence of optical nonlinearity of the chalcone derivatives on the phonon characteristic energy will help in designing similar class of new molecules with high nonlinear coefficients.
Zeolite-based hybrid material as an efficient promoter in the green synthesis of mono/bis-phthalazinones
Bodaghifard, Mohammad Ali,Ghasemi, Meisam,Hamidinasab, Mahdia
, p. 3435 - 3448 (2021/09/29)
Hybrid structures containing organic-inorganic porous materials are of great interest as green, heterogeneous, and recyclable catalysts. In this study, a novel organic-inorganic hybrid material (Zeolite HY@DETA) via the surface-functionalization of the Zeolite HY was prepared. The structure of hybrid material was characterized using the Fourier-transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FE-SEM), Energy-dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET) surface area analysis. Subsequently, the catalytic activity of this novel hybrid material was considered in the one-pot three-component synthesis of 3-amino-1-aryl-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile and some bis phthalazine-dione derivatives under green and environmentally benign conditions. The products were synthesized in excellent yields within a short reaction time and identified using elemental analysis, FT-IR, 1H NMR, and 13C NMR spectroscopies. This protocol avoids the use of harmful catalysts, toxic solvents, and harsh reaction conditions. Besides, the catalyst could be recycled for five reaction runs with a slight loss of catalytic activity.
(±)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in vitro evaluation and SAR analysis
Bernal, Freddy A.,Gerhards, Marcel,Kaiser, Marcel,Wünsch, Bernhard,Schmidt, Thomas J.
, (2020/08/06)
Leishmaniasis, a neglected tropical disease caused by parasites of the genus Leishmania, causes a serious burden of disease around the world, represents a threat to the life of millions of people, and therefore is a major public health problem. More effective and non-toxic new treatments are required, especially for visceral leishmaniasis, the most severe form of the disease. On the backdrop that dihydrobenzofurans have previously shown antileishmanial activity, we present here the synthesis of a set of seventy trans-2-phenyl-2,3-dihydrobenzofurans and evaluation of their in vitro activity against Leishmania donovani as well as a discussion of structure-activity relationships. Compounds 8m-o and 8r displayed the highest potency (IC50 4.6). Nonetheless, structural optimization as further requirement was inferred from the high clearance of the most potent compound (8m) observed during determination in vitro of its metabolic stability. On the other hand, chiral separation of 8m and subsequent biological evaluation of its enantiomers demonstrated no effect of chirality on activity and cytotoxicity. Holistic analysis of in silico ADME-like properties and ligand efficiency metrics by a simple scoring function estimating druglikeness highlighted compounds 16c, 18 and 23 as promising candidates for further development. Overall, the potential of trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents was confirmed.
