30113-83-8

Usage

InChI:InChI=1/C10H6O5/c11-5-1-2-6-7(12)4-9(10(13)14)15-8(6)3-5/h1-4,11H,(H,13,14)

Upstream product

• 860189-36-2 4-(4-benzyloxy-2-hydroxy-phenyl)-2,4-dioxo-butyric acid ethyl ester 
• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 
• 102297-81-4 ethyl 6,8-diiodo-7-hydroxy-4-oxochromene-2-carboxylate 
• 28466-90-2 ethyl 7-hydroxy-8-iodo-4-oxochromene-2-carboxylate 
• 23866-72-0 ethyl 7-hydroxy-4-oxo-4H-chromen-2-carboxylate 
• 102297-82-5 ethyl 8-cyano-7-hydroxy-4-oxochromene-2-carboxylate 
• 6345-73-9 7-benzyloxy-4-oxo-4H-chromene-2-carboxylic acid ethyl ester 

Downstream Products

• 6665-86-7 7-hydroxyflavone 
• 102026-86-8 1-(7-hydroxy-chroman-6-yl)-ethanone-(2,4-dinitro-phenylhydrazone) 
• 57052-72-9 2,3-Dihydro-7-hydroxy-4H-1-benzopyran 
• 76240-27-2 7-hydroxy-2,3-dihydro-4H-chromen-4-one 
• 59887-89-7 7-hydroxy-4H-chromen-4-one 

Relevant academic research and scientific papers

SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

ANTI-INFECTIVE AGENTS

The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

Chromone complexes

The invention relates to complexes of certain chromone derivatives, to compositions which comprise such derivatives, to corresponding processes for the preparation of the chromone derivatives or of compositions comprising same, and to the use thereof, in particular for the care, maintenance or improvement of the general state of the skin or hair.

Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: Assessment of potency, efficacy, and cardiovascular safety

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a chromone-2-carboxamide series as having excellent safety against the chosen cardiovascular endpoints at high drug concentrations in the plasma and brain. Optimization of this series led to considerable improvements in affinity, functional potency, and pharmacokinetic profile. This led to the identification of a 7-fluorochromone-2-carboxamide (22) that was orally efficacious in a diet-induced obese mouse model, retained a favorable cardiovascular profile in rat, and demonstrated dramatic improvement in effects on mean arterial pressure in our dog cardiovascular model compared to other series reported by our group. However, this analogue also led to prolongation of the QT interval in the dog that was linked to affinity for hERG channel and unexpectedly potent functional blockade of this ion channel.

CHROMEN-4-ONE DERIVATIVES

The invention relates to compounds that are selected from the compounds of formulas (Ia)-(Ic) and to their production and use in cosmetic and dermatological products.

CHROMONE COMPLEXES

The invention relates to complexes of certain chromone derivatives, preparations containing such derivatives, corresponding methods for producing chromone derivatives or preparations containing the same, and to the use thereof, especially for skin or hair care and for preserving or improving the general condition of the skin or hair.

SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS

The present invention relates to novel substituted piperidine and piperazine derivatives as melanocortin-4 receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes and s

Benzopyrones. Part 22. Synthesis of New 4-Oxochromene Polycarboxylic Acids

The synthesis of the following chromone dicarboxylic acids is described: 4-oxochromene-2,7-dicarboxylic acid, 6-methyl-4-oxochromene-2,8-dicarboxylic acid, 7-hydroxy-4-oxochromene-2,8-dicarboxylic acid, and 4-oxochromene-3,6-dicarboxylic acid. 4-Oxochromene-2,3-dicarboxylic acid 2-ethyl ester has been synthesized as well as 4-oxochromene-2,6,8-tricarboxylic acid.Some derivatives of these acids are described and the relative stability of carboxy groups attached to the chromen-4-one ring system is discussed.