301155-73-7Relevant academic research and scientific papers
Investigations into the oxidative stability of hydroxymethyl- and bis(hydroxymethyl)-phosphines
Griffiths,Groombridge,Salt
experimental part, p. 473 - 478 (2009/04/04)
Polydentate ligands containing the bis(hydroxymethyl)phosphine unit have been reported to exhibit enhanced oxidative stability, which would make them attractive for use in 99mTc-radiopharmaceutical imaging agents. Benzylethyl(hydroxymethyl)phosphine, benzylbis(hydroxymethyl)phosphine and benzyldiethylphosphine were prepared in order to investigate the origin of this oxidative stability. Little evidence was found to indicate that the hydroxymethylphosphines show an enhanced level of stability, but it was demonstrated that the reaction conditions employed in their preparation generated a number of closely related by-products, which are likely to limit the usefulness of the hydroxymethylphosphines in commercial radiopharmaceutical applications. Copyright Taylor & Francis Group, LLC.
