301168-95-6Relevant academic research and scientific papers
Selective Generation of (1H-1,2,4-Triazol-1-yl)methyl Carbanion and Condensation with Carbonyl Compounds
Lassalas, Pierrik,Claraz, Aurélie,Tran, Ga?l,Vors, Jean-Pierre,Tsuchiya, Tomoki,Coqueron, Pierre-Yves,Cossy, Janine
, p. 6991 - 6996 (2017)
2-(1H-1,2,4-Triazol-1-yl)ethanols have received significant interest in agricultural and medicinal chemistry owing to their herbicidal and antifungal activities. To develop a versatile method to access these substituted triazoles, we explored the generation of the (1H-1,2,4-triazol-1-yl)methyl carbanion and its condensation with carbonyl compounds. By judicious choice of a suitable anion precursor (tributylstannyl group) or a stabilizing anion group (phenylsulfanyl or phenylsulfinyl group), a wide range of aldehydes and ketones reacted with the carbanions to give a large diversity of 2-(1H-1,2,4-triazol-1-yl)ethanols in good yields.
Azoles. Part 43:1 reactions of N-(phenylsulphonylmethyl)- and N-(phenylsulphinylmethyl)azoles with some nitroarenes
Bernard, Marek K
, p. 7273 - 7284 (2007/10/03)
Treatment of nitroarenes with 1-(phenylsulphonylmethyl)azoles in the KOH/DMSO system at room temperature resulted usually in the cleavage of the phenylsulphonyl group, whereas the t-BuOK/DMF system at low temperature promotes to a greater extent oxidation of the σ-adducts. When 1-(phenylsulphinylmethyl)azoles were used for the reaction only elimination of the phenylsulphinyl group was observed. (C) 2000 Elsevier Science Ltd.
