301201-62-7Relevant academic research and scientific papers
Synthesis of 2-Hydrazolyl-4-Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi
Pizzo, Chiara,Saiz, Cecilia,Talevi, Alan,Gavernet, Luciana,Palestro, Pablo,Bellera, Carolina,Blanch, Luis Bruno,Benitez, Diego,Cazzulo, Juan J.,Chidichimo, Agustina,Wipf, Peter,Mahler, S. Graciela
, p. 166 - 172 (2011)
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37μm concentration in the enzyme assay. Computational tools and docking were used to correlate the biological response with the physicochemical parameters of the compounds and their cruzipain inhibitory effects.
Synthesis, structures and antimicrobial activity of chloro- And fluoro-substituted thiocarboxyhydrazones
Liu, Zeng-Xin
, p. 2872 - 2875 (2015)
A series of chloro- And fluoro-substituted thiocarboxyhydrazones, 2-(2-chlorobenzylidene)-N-methylhydrazinecarbothioamide (1), 2-(4-fluorobenzylidene)- N-methylhydrazinecarbothioamide (2), and 2-(2-chloro-4-fluorobenzylidene)-N-methylhydrazinecarbothioami
Inhibitions of monoamine oxidases and acetylcholinesterase by 1-methyl, 5-phenyl substituted thiosemicarbazones: Synthesis, biochemical, and computational investigations
Jayanthi, Sivaraman,Kim, Hoon,Kumar, Kumudhavalli Suresh,Mathew, Bijo,Mathew, Githa Elizabeth,Mohan, Kumar,Oh, Jong Min
, p. 246 - 253 (2020/10/02)
A series of eleven 1-methyl, 5-phenyl substituted thiosemicarbazones (MT1–MT11) with the phenyl ring substitutions were prepared and investigated for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). [4-(dimeth
