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30123-17-2

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Tianeptine Sodium/ free acid/sulfate CAS 30123-17-2 for Anti-Depressant with Safe Delivery
Cas No: 30123-17-2
USD $ 10.0-10.0 / Gram 1 Gram 10 Kilogram/Day Hubei Vanz Pharm Co.,Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support Tianeptine sodium salt CAS 30123-17-2
Cas No: 30123-17-2
USD $ 15.0-15.0 / Gram 1 Gram 900 Kilogram/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
US warehouse High quality 99% Tianeptine sodium / sodium Tianeptine CAS NO.30123-17-2
Cas No: 30123-17-2
USD $ 5.0-5.4 / Gram 1 Gram 100 Kilogram/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Tianeptine Sodium EP or Tianeptine Acid Stock
Cas No: 30123-17-2
No Data 100 Gram 200 Kilogram/Month Hangzhou Think Chemical Co. Ltd Contact Supplier
Factory supply purity 99% cas 30123-17-2 Tianeptine Sodium Salt
Cas No: 30123-17-2
USD $ 100.0-150.0 / Gram 10 Gram 8000 Kilogram/Month Hebei Yingong New Material Technology Co.,Ltd . Contact Supplier
ChemicalTianeptine Sodium Salt Powder 99% 30123-17-2 Tianeptine Sodium
Cas No: 30123-17-2
No Data 100 Gram 10 Metric Ton/Month Shanghai CRM New Material Technology Co., LTD Contact Supplier
Tianeptine sodium salt
Cas No: 30123-17-2
USD $ 661.7-661.7 / Metric Ton 1 Metric Ton 1000 Kilogram/Month Career Henan Chemical Co Contact Supplier
Tianeptine Sodium/ Tianeptine acid/Tianeptine sulfate CAS 30123-17-2 for Anti-Depressant with Safe Delivery from USA warehouse
Cas No: 30123-17-2
USD $ 2200.0-2800.0 / Kilogram 1 Kilogram 50 Kilogram/Month Mike(Wuhan) Biotechnology Co.,Ltd Contact Supplier
High quality Tianeptine Sodium
Cas No: 30123-17-2
USD $ 100.0-100.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Metric Ton/Day Zibo Hangyu Import&Export Co., Ltd Contact Supplier
High quality Tianeptine sodium/CAS NO. 30123-17-2
Cas No: 30123-17-2
USD $ 1800.0-1950.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Binbo Biological Co., Ltd Contact Supplier

30123-17-2 Usage

Brand name

STABLON

Uses

Tianeptine sodium salt hydrate has been used as a selective serotonin reuptake enhancer (SSRE) positive control during serotonin transporter (SERT) assay in human embryonic kidney 293 cell lines.

Appearance

White to pale yellow solid.

Description

Tianeptine sodium is a structurally novel, serotonin specific antidepressant. It is useful in the treatment of neurotic and reactive depressions, as well as depressive states accompanied by anxiety.

Chemical Properties

White to Yellowish Powder

Uses

Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant

Uses

Tianeptine (INN) (Stablon, Coaxil, Tatinol) is a selective serotonin reuptake enhancer (SSRE) drug used for treating major depressive episodes (mild, moderate, or severe). Unlike conventional tricyclic antidepressants, tianeptine enhances the reuptake of

Manufacturing Process

A solution of 27.6 g (0.16 mol) of freshly distilled ethyl 7-aminoheptanoate in 40 ml of nitromethane was added all at once and with mechanical stirring to a suspension of 26.2 g (0.08 mol) of 5,8-dichloro-10-dioxo-11- methyldibenzo[c,f]thiazepine(1,2) in 120 ml of nitromethane. The whole was heated to 55°C for 30 minutes, the solvent was then evaporated in vacuo and the residue was taken up in water. The crude ester was extracted with ether. After evaporation of the ether 36 g of crude ester were obtained, and 30 g (0.065 mol) there of were treated under reflux with a solution of 2.8 g (0.07 mol) of sodium hydroxide in 35 ml of ethanol and 25 ml of water. After one hour's refluxing, the alcohol was evaporated in vacuo. The residue was taken up in 150 ml of water. The mixture was twice extracted with 75 ml of chloroform and the aqueous phase was evaporated in vacuo. The sodium salt was then dissolved in 150 ml of chloroform, the solution was dried over sodium sulfate and the product precipitated with anhydrous ether. The salt was filtered off, washed with ether and dried at 50°C. 13 g of sodium 7-[8-chloro-10-dioxo-11-methyldibenzo[c,f]thiazepin-(1,2)-aminoheptanoate,melting with decomposition at about 180°C, were obtained.

Biological Activity

Selective facilitator of 5-HT uptake in vitro and in vivo . Has no affinity for a wide range of receptors, including 5-HT and dopamine (IC 50 > 10 μ M) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo .

Biochem/physiol Actions

Tianeptine is a tricyclic antidepressant that enhances serotonin uptake. This drug can affect neuroprotection, neuronal excitability, memory and anxiety. However, tianeptine is not linked to adverse psychomotor, cognitive, cardiovascular, sleep and bodyweight effects. The drug has a low tendency for abuse and has a positive pharmacokinetic profile. Tianeptine is least involved in drug interaction as it is not metabolized by cytochrome P450 system in the liver. In hippocampus and amygdala, tianeptine is involved in glutamatergic transmission processes and elicits neuroplasticity.

Therapeutic Function

Antidepressant

Laboratory Procedures

Tianeptine (sodium salt) is supplied as a crystalline solid. A stock solution may be made by dissolving the tianeptine (sodium salt) in the solvent of choice. Tianeptine (sodium salt) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of tianeptine (sodium salt) in these solvents is approximately 10, 20, and 30 mg/ml, respectively. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of tianeptine (sodium salt) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of tianeptine (sodium salt) in PBS, pH 7.2, is approximately 10 mg/ml. We do not recommend storing the aqueous solution for more than one day.

Description

Tianeptine sodium salt is a salt of Tianeptine. Tianeptine is an atypical antidepressant. It is an agonist of the μ-opioid receptor (MOR; EC50s = 194 and 641 nM for human and mouse receptors, respectively, in a BRET assay for G protein activation) and also has effects on the glutamate system. Tianeptine (30 mg/kg) decreases immobility in the forced swim test in wild-type, but not MOR knockout mice, indicating antidepressant-like activity dependent on MORs. It increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test and increases paw withdrawal latency in the hot-plate test in mice. Tianeptine modulates AMPA receptor activity by increasing phosphorylation of the AMPA receptor GluR1 subunit in the frontal cortex and hippocampal CA3 region in mice. It prevents increases in glial glutamate transporter 1 (GLT-1) expression induced by chronic restraint stress in the hippocampal CA3 region in rats when administered at a dose of 10 mg/kg per day for 21 days.5It also reverses increases in extracellular glutamate levels induced by acute restraint stress in the basolateral nucleus of the amygdala in rats.

biological activity

Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. IC50 Value:Target: 5-HT ReceptorTianeptine has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50 > 10 μM) and has no effect on noradrenalin or dopamine uptake. Antidepressant, analgesic and neuroprotective following systemic administration in vivo.

Originator

Sci. Union et Cie (France)
InChI:InChI=1/C21H25ClN2O4S.Na/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);/q;+1

30123-17-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (T3131)  Tianeptine Sodium Salt Hydrate  >98.0%(HPLC)(N) 30123-17-2 200mg 590.00CNY Detail
TCI America (T3131)  Tianeptine Sodium Salt Hydrate  >98.0%(HPLC)(N) 30123-17-2 1g 1,990.00CNY Detail
Sigma-Aldrich (Y0000152)  Tianeptine for system suitability  European Pharmacopoeia (EP) Reference Standard 30123-17-2 Y0000152 1,880.19CNY Detail
Sigma (T1692)  Tianeptine sodium salt hydrate  ≥98% (HPLC), powder 30123-17-2 T1692-5MG 2,887.56CNY Detail
Sigma (T1692)  Tianeptine sodium salt hydrate  ≥98% (HPLC), powder 30123-17-2 T1692-25MG 10,407.15CNY Detail

30123-17-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Tianeptine sodium salt hydrate

1.2 Other means of identification

Product number -
Other names Tianeptine sodium salt,7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoicacidsodiumsalt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:30123-17-2 SDS

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