301307-97-1Relevant academic research and scientific papers
NOVEL INHIBITORS
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Page/Page column 109, (2011/05/03)
The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
Stereoselective Synthesis of 1,2-Disubstituted β-Amino Alcohols by Nucleophilic Addition to N-tert-Butanesulfinyl α-Alkoxyaldimines
Evans, Jared W.,Ellman, Jonathan A.
, p. 9948 - 9957 (2007/10/03)
N-tert-Butanesulfinyl α-alkoxyaldimines are readily prepared from protected (S)-lactals without epimerization at the α-stereocenter. Addition of ethyl and phenyl Grignard reagents, as well as the titanium enolate of methyl acetate, to the N-tert-butanesul
Process for preparing β-hydroxycarbamates and their conversion to oxazolidinones
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Example 3, (2008/06/13)
A process for preparing a β-hydroxy carbamate product is disclosed. The process comprises reacting an olefin compound containing at least one carbon-carbon double bond with a carbamate in an aqueous solvent and in the presence of a base, an osmium catalys
Practical modifications and applications of the sharpless asymmetric aminohydroxylation in the one-pot preparation of chiral oxazolidin-2-ones
Barta, Nancy S.,Sidler, Daniel R.,Somerville, Kara B.,Weissman, Steven A.,Larsen, Robert D.,Reider, Paul J.
, p. 2821 - 2824 (2007/10/03)
Chiral oxazolidin-2-ones are synthetically valuable as chiral auxiliaries, and many have pharmaceutically interesting biological activity. This communication focuses on a convenient, practical one-pot preparation of chiral 4,5-disubstituted oxazolidan-2-o
