30131-49-8

Upstream product

• 141-97-9 ethyl acetoacetate 
• 552-89-6 2-nitro-benzaldehyde 
• 21829-26-5 diethyl 4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 

Downstream Products

• 846595-13-9 2,6-dimethyl-4-(2-nitro-phenyl)-nicotinic acid ethyl ester 
• 98918-07-1 2-Methyl-4-(2-nitro-phenyl)-5-oxo-5,6-dihydro-[1,6]naphthyridine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Biomimetic aromatization of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by a new polystyrene-bound manganese porphyrin

Efficient oxidation of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by a polystyrene-bound manganese(III) porphyrin is reported. This catalyst shows high activity in the oxidation of various 1,4-dihydropyridines at room temperature. This

Aromatization of hantzsch 1,4-dihydropyridine with bismuth(III) chloride supported onto wet HZSM-5 zeolite under microwave irradiation in solventless system

Hantzsch 1,4-dihydropyridines (1,4 DHPs) can be aromatized to pyridines by bismuth(III) chloride supported onto wet HZSM-5 zeolite under microwave irradiation in high yields and in a short time. Copyright Taylor & Francis Inc.

TEMPO supported amine functionalized magnetic titania: a magnetically recyclable catalyst for the aerobic oxidative synthesis of heterocyclic compounds

Abstract: The present protocol uncover a new strategy to synthesize highly efficient solid TEMPO based catalyst in which 4-oxo-TEMPO was covalently tethered to the surface of amine functionalized magnetic titania. The chemical nature and structure of the

Iodobenzene diacetate (IBD) catalyzed an quick oxidative aromatization of Hantzsch-1,4-dihydropyridines to pyridines under ultrasonic irradiation

This project was undertaken to demonstrate the potential of iodobenzene diacetate for the oxidative aromatization of Hantzch-1,4-dihydropyridines under ultrasonic irradiation. All reactions were carried out under ultrasonic irradiation and results were co

One-pot synthesis of hantzsch dihydropyridine catalyzed by ionic liquid (BmimOAc) and the oxidative aromatization of dihydropyridine using FeCl 3·6H2O

A series of 1,4-dihydropyridines were synthesized in one pot synthesis with the yield of 80-93 % using ionic liquid [bmim]OAc as catalyst and DMF as solvent. The ionic liquid could be repeatedly utilized 5 times with no decrease of the yield. The aromatization of these dihydropyridines (4a, 4b, 4d, 4f, 4h and 4i) were executed by the action of iron chloride and the post-processing was simplified using ethanol instead of water in dissolving dihydropyridines.

Oxidation of 1,4-dihydropyridines and 3,4-dihydropyrimidin-2(1H)-ones to substituted pyridines and pyrimidinones using Ca(OCl)2 in aqueous media

1,4-Dihydropyridines and 3,4-dihydropyrimidin-2(1H)-ones obtained from the Hantzsch and Biginelli reactions undergo readily oxidative dehydrogenation by using calcium hypochlorite in very short times. These calcium stimulator drugs were oxidized under rea

Oxidative aromatization of Hantzsch 1,4-dihydropyridines by sodium chlorite

Hantzsch 1,4-dihydropyridines were converted to the corresponding pyridines efficiently by sodium chlorite under mild conditions in excellent yields.

A novel, facile, simple and convenient oxidative aromatization of Hantzsch 1,4-dihydropyridines to pyridines using polymeric iodosobenzene with KBr

An easy, safe, effective and handy method for oxidative aromatization of Hantzsch 1,4-dihydropyridines catalyzed by hypervalent iodine (iodosobenzene) and potassium bromide to corresponding pyridine derivatives in high-yields and within short span of time was described. Dealkylation in case of 4-n-alkyl substituted 1,4-dihydropyridines was not obtained.

An expeditious oxidative aromatization of hantzsch 1,4-dihydropyridines to pyridines using cetyltrimethylammonium peroxodisulfate: A phase transferring oxidant

A new approach to the use of potassium peroxodisulphate as an oxidizing reagent is proposed and applied to the case of oxidative aromatization of 1, 4-dihydropyridines with cetyltrimethylammonium peroxodisulfate, a phase transfer oxidant. We demonstrate h

Catalytic effect of basic alumina in the dehydrogenation of 1,4-Dihydropyridines with tetrabutylammonium peroxydisulfate

4-Alkyl- or 4-aryl-1, 4-dihydropyridine derivatives were oxidized to the pyridine derivatives by tetrabutylammonium peroxydisulfate (n-Bu 4N)2S2O8 (TBAPD) in combination with basic alumina in refluxing acetonitr