CID5721353 is an inhibitor of the transcriptional repressor B cell lymphoma 6 (Bcl-6) with a Ki value of 147 μM. It demonstrates selectivity for Bcl-6 over other related proteins such as Kaiso, HIC1, and PLZF at a concentration of 50 μM. CID5721353 has shown cytotoxic effects against Bcl-6-dependent diffuse large B cell lymphoma (DLBCL) cell lines and has the potential to increase the expression of Bcl-6 target genes in certain cell types. Additionally, CID5721353 has been observed to reduce tumor growth in mouse xenograft models at a dosage of 50 mg/kg.
301356-95-6
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Basic information
- Product Name: CID5721353
- Synonyms: CID5721353;CID5721353, BCL6 inhibitor;BCL6 inhibitor(CID5721353);CID5721353 BDL6 inhribitor
- CAS NO:301356-95-6
- Molecular Formula: C15H9BrN2O6S2
- Molecular Weight: 457.27576
- EINECS: N/A
- Product Categories: API
- Mol File: 301356-95-6.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: 2.06±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 3.02±0.23(Predicted)
- CAS DataBase Reference: CID5721353(CAS DataBase Reference)
- NIST Chemistry Reference: CID5721353(301356-95-6)
- EPA Substance Registry System: CID5721353(301356-95-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 301356-95-6(Hazardous Substances Data)
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301356-95-6 Usage
Uses
Used in Oncology Research:CID5721353 is used as a research tool for studying the role of Bcl-6 in various types of cancer, particularly diffuse large B cell lymphoma (DLBCL). Its ability to selectively inhibit Bcl-6 makes it a valuable compound for understanding the underlying mechanisms of Bcl-6-dependent tumor growth and progression.
Used in Drug Development:
CID5721353 serves as a potential therapeutic agent for the treatment of Bcl-6-dependent cancers. Its cytotoxic effects on specific cancer cell lines and its capacity to modulate the expression of Bcl-6 target genes suggest that it may have potential in the development of targeted cancer therapies.
Used in Preclinical Cancer Models:
CID5721353 is used as a compound for testing in preclinical cancer models, such as mouse xenograft models, to evaluate its efficacy in reducing tumor growth and to assess its potential as a therapeutic agent for Bcl-6-dependent cancers.
Used in Pharmaceutical Industry:
CID5721353 is utilized in the pharmaceutical industry for the development of novel drugs targeting Bcl-6-dependent cancers. Its selectivity and cytotoxic properties make it a promising candidate for further research and development into potential cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 301356-95-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,1,3,5 and 6 respectively; the second part has 2 digits, 9 and 5 respectively.Calculate Digit Verification of CAS Registry Number 301356-95:
(8*3)+(7*0)+(6*1)+(5*3)+(4*5)+(3*6)+(2*9)+(1*5)=106
106 % 10 = 6
So 301356-95-6 is a valid CAS Registry Number.
301356-95-6Upstream product
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CID5721353
