301535-34-2Relevant academic research and scientific papers
Asymmetric conjugate additions of chiral phosphonamide anions to α,β-unsaturated carbonyl compounds. A versatile method for vicinally substituted chirons
Hanessian, Stephen,Gomtsyan, Arthur,Malek, Nadia
, p. 5623 - 5631 (2007/10/03)
Reactions of anions derived from chiral nonracemic allyl, crotyl, and cinnamyl bicyclic C2-symmetrical phosphonamides with α,β-unsaturated cyclic ketones, esters, lactones, and lactams take place at the γ-position of the reagents. The products are diastereomerically pure or enriched β-substituted carbonyl compounds. The method also provides easy access to vicinal substitution of as many as three stereogenic centers including in some cases quaternary carbon atoms, in a one-pot sequence.
