301649-59-2Relevant academic research and scientific papers
Asymmetric synthesis of amino sugars. Part 2. A novel versatile approach to the chiral non-racemic synthesis of 2-amino-2-deoxy sugars. Preparation of L-glucosamine, L-mannosamine and L-talosamine derivatives
Ermolenko, Ludmila,Sasaki, N. Andre,Potier, Pierre
, p. 2465 - 2473 (2000)
The asymmetric synthesis of 2-amino-2-deoxy sugars, starting from chiral building block and 2,3-O-isopropylideneglyceraldehyde via Julia olefination and subsequent dihydroxylation was discussed. The essential feature of the process is the transformation of the readily available building blocks into a fully protected derivative of 2-amino polyol followed by cyclization to 2-amino-2-deoxy sugar. The versatility of the approach was exemplified by the preparation of L-glucosamine, L-mannosamine and L-talosamine derivatives in highly diastereometrically pure forms.
