301662-22-6Relevant academic research and scientific papers
Functionalized platforms based on marine cyclopeptides: Different pathways to the hexapeptide
Boss,Rasmussen,Wartini,Waldvogel
, p. 6327 - 6331 (2000)
The synthesis of macrocyclic, roughly planar, exclusively syn-functionalized hexapeptides, related to dolastatin I and bistratamide C from enantiomerically pure oxazole precursors is reported. The platforms can either be synthesized in a stepwise procedure by final cyclization of the linear oxazole trimers or in a direct 'one-pot' reaction. The investigation on the coupling of these building blocks into linear dimers and trimers with modern peptide coupling reagents is reported. (C) 2000 Published by Elsevier Science Ltd.
